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Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Intra-laboratory assessment of a method for the detection of TiO2 nanoparticles present in sunscreens based on multi-detector asymmetrical flow field-flow fractionation
Autor Velimirovic, M.; Wagner, S.; Koeber, R.; Hofmann, T.; von der Kammer, F.;
Journal / Serie NanoImpact
Erscheinungsjahr 2020
Department ANA;
Band/Volume 19
Sprache englisch;
POF III (gesamt) T42;
Keywords TiO2 nanoparticles in sunscreen; Sample preparation; Asymmetrical flow field-flow fractionation; Multi angle light scattering; ICP-MS; In-house validation
Abstract In this study, an intra-laboratory assessment was carried out to establish the effectiveness of a method for the detection of TiO2 engineered nanoparticles (ENPs) present in sunscreen containing nano-scale TiO2 and a higher nanometer-range (approx. 200–500 nm) TiO2, as well as iron oxide particles. Three replicate measurements were performed on five separate days to generate the measurement uncertainties associated with the quantitative asymmetrical flow field-flow fractionation (AF4) measurement of the hydrodynamic radius rh,mode1 (MALS), rh,mode1 (ICP-MS), rh,mode2 (ICP-MS), and calculated mass-based particle size distribution (d10, d50, d90). The validation study demonstrates that the analysis of TiO2 ENPs present in sunscreen by AF4 separation-multi detection produces quantitative data (mass-based particle size distribution) after applying the sample preparation method developed within the NanoDefine project with uncertainties based on the precision (uIP) of 3.9–8.8%. This method can, therefore, be considered as the method with a good precision. Finally, the bias data shows that the trueness of the method (ut = 5.5–52%) can only be taken as a proxy due to the lack of a sunscreen standard containing certified TiO2 ENPs.
ID 23283
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=23283
Velimirovic, M., Wagner, S., Koeber, R., Hofmann, T., von der Kammer, F. (2020):
Intra-laboratory assessment of a method for the detection of TiO2 nanoparticles present in sunscreens based on multi-detector asymmetrical flow field-flow fractionation
NanoImpact 19 , art. 100233