Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Phthalate exposure during the prenatal and lactational period increases the susceptibility to rheumatoid arthritis in mice
Autor Elter, E.; Wagner, M.; Buchenauer, L.; Bauer, M.; Polte, T.;
Journal / Serie Frontiers in Immunology
Erscheinungsjahr 2020
Department IMMU;
Band/Volume 11
Sprache englisch;
POF III (gesamt) F11; T42;
Supplements https://ndownloader.figshare.com/collections/4921107/versions/1
Keywords perinatal exposure; rheumatoid arthritis; phthalate; early programming; autoimmune disease INTRODUCTION
Abstract The prenatal and early postnatal period is highly sensitive to environmental exposures that may interfere with the developmental programming of the immune system leading to an altered disease risk in later life. To clarify the role of early influences in activation or exacerbation of autoimmune diseases like rheumatoid arthritis (RA) we investigated the effect of maternal exposure during the prenatal and lactational period of DBA/1 mice to the plasticizer benzyl butyl phthalate (BBP) on the development of RA in the offspring. Using a mild collagen-induced arthritis (CIA) model, maternal BBP-exposure increased both the prevalence and the severity of RA in the progeny compared to un-exposed dams. Additionally, maternal BBP exposure led to elevated serum IgG1 and IgG2a level in the offspring and increased the IFN-γ and IL-17 release from collagen-re-stimulated spleen cells. Transcriptome analysis of splenocytes isolated from 3-week-old pups before RA-induction revealed considerable changes in gene expression in the offspring from BBP-exposed dams. Among them were regulator of G-protein signaling 1 (rgs1), interleukin-7 receptor (il-7r) and CXC chemokine 4 (cxcr4), all genes that have previously been described as associated with RA pathology. In summary, our results demonstrate that perinatal exposure to BBP increases the susceptibility of the offspring to RA, probably via a phthalate-induced disturbed regulation of RA-relevant genes or signaling pathways.
ID 23035
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=23035
Elter, E., Wagner, M., Buchenauer, L., Bauer, M., Polte, T. (2020):
Phthalate exposure during the prenatal and lactational period increases the susceptibility to rheumatoid arthritis in mice
Front. Immunol. 11 , art. 550