Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1002/elsc.201800198
Lizenz creative commons licence
Titel (primär) Early‐stage sustainability assessment of biotechnological processes: A case study of citric acid production
Autor Becker, M.-Y.; Kohlheb, N.; Hunger, S.; Eschrich, S.; Müller, R.; Aurich, A.
Quelle Engineering in Life Sciences
Erscheinungsjahr 2020
Department UBZ
Band/Volume 20
Heft 3-4
Seite von 90
Seite bis 103
Sprache englisch
Keywords bioprocess design; citric acid; early‐stage sustainability assessment; life‐cycle assessment; Yarrowia lipolytica
Abstract Sustainability assessment using a life‐cycle approach is indispensable to contemporary bioprocess development. This assessment is particularly important for early‐stage bioprocess development. As early‐stage investigations of bioprocesses involve the evaluation of their ecological and socioeconomic effects, they can be adjusted more effectively and improved towards sustainability, thereby reducing environmental risk and production costs. Early‐stage sustainability assessment is an important precautionary practice and, despite limited data, a unique opportunity to determine the primary impacts of bioprocess development. To this end, a simple and robust method was applied based on the standardized life‐cycle sustainability assessment methodology and commercially available datasets. In our study, we elaborated on the yeast‐based citric acid production process with Yarrowia lipolytica assessing 11 different substrates in different process modes. The focus of our analysis comprised both cultivation and down‐stream processing. According to our results, the repeated batch raw glycerol based bioprocess alternative showed the best environmental performance. The second‐ and third‐best options were also glycerol‐based. The least sustainable processes were those using molasses, chemically produced ethanol, and soy bean oil. The aggregated results of environmental, economic, and social impacts display waste frying oil as the best‐ranked alternative. The bioprocess with sunflower oil in the batch mode ranked second. The least favorable alternatives were the chemically produced ethanol‐, soy oil‐, refined glycerol‐, and molasses‐based citric acid production processes. The scenario analysis demonstrated that the environmental impact of nutrients and wastewater treatment is negligible, but energy demand of cultivation and down‐stream processing dominated the production process. However, without energy demand the omission of neutralizers almost halves the total impact, and neglecting pasteurization also considerably decreases the environmental impact.
dauerhafte UFZ-Verlinkung
Becker, M.-Y., Kohlheb, N., Hunger, S., Eschrich, S., Müller, R., Aurich, A. (2020):
Early‐stage sustainability assessment of biotechnological processes: A case study of citric acid production
Eng. Life Sci. 20 (3-4), 90 - 103 10.1002/elsc.201800198