Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1016/j.jhazmat.2019.01.103
Volltext Akzeptiertes Manuskript
Titel (primär) Microbial transformation of chiral organohalides: Distribution, microorganisms and mechanisms
Autor Lu, Q.; Qiu, L.; Yu, L.; Zhang, S.; Alves de Toledo, R.; Shim, H.; Wang, S.
Journal / Serie Journal of Hazardous Materials
Erscheinungsjahr 2019
Department OEC
Band/Volume 368
Seite von 849
Seite bis 861
Sprache englisch
Keywords Chiral organohalides; Enantioselectivity; Microbial transformation; Enantioselective dehalogenation; Enantiomeric fraction (EF)
Abstract Chiral organohalides including dichlorodiphenyltrichloroethane (DDT), Hexabromocyclododecane (HBCD) and polychlorinated biphenyls (PCBs) raise a significant concern in the environmental occurrence, fate and ecotoxicology due to their enantioselective biological effects. This review provides a state-of-the-art overview on enantioselective microbial transformation of the chiral organohalides. We firstly summarized worldwide field assessments of chiral organohalides in a variety of environmental matrices, which suggested the pivotal role of microorganisms in enantioselective transformation of chiral organohalides. Then, laboratory studies provided experimental evidences to further link enantioselective attenuation of chiral organohalides to specific functional microorganisms and enzymes, revealing mechanistic insights into the enantioselective microbial transformation processes. Particularly, a few amino acid residues in the functional enzymes could play a key role in mediating the enantioselectivity at the molecular level. Finally, major challenges and further developments toward an in-depth understanding of the enantioselective microbial transformation of chiral organohalides are identified and discussed.
dauerhafte UFZ-Verlinkung
Lu, Q., Qiu, L., Yu, L., Zhang, S., Alves de Toledo, R., Shim, H., Wang, S. (2019):
Microbial transformation of chiral organohalides: Distribution, microorganisms and mechanisms
J. Hazard. Mater. 368 , 849 - 861