Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) High‐throughput screening and environmental risk assessment: State of the science and emerging applications
Autor Villeneuve, D.L.; Coady, K.; Escher, B.I.; Mihaich, E.; Murphy, C.; Schlekat, T.; Garcia-Reyero, N.;
Journal / Serie Environmental Toxicology and Chemistry
Erscheinungsjahr 2019
Department ZELLTOX;
Band/Volume 38
Heft 1
Sprache englisch;
POF III (gesamt) T42;
Keywords Computational toxicology; Adverse outcome pathway; Effects‐based monitoring; In vitro to in vivo extrapolation; Risk assessment; Mixtures
UFZ Querschnittsthemen CITEPro;
Abstract In 2007 the United States National Research Council (NRC) published a vision for toxicity testing in the 21st century that emphasized the use of in vitro high‐throughput screening (HTS) methods and predictive models as an alternative to in vivo animal testing. In the present study we examine the state of the science of HTS and the progress that has been made in implementing and expanding on the NRC vision, as well as challenges to implementation that remain. Overall, significant progress has been made with regard to the availability of HTS data, aggregation of chemical property and toxicity information into online databases, and the development of various models and frameworks to support extrapolation of HTS data. However, HTS data and associated predictive models have not yet been widely applied in risk assessment. Major barriers include the disconnect between the endpoints measured in HTS assays and the assessment endpoints considered in risk assessments as well as the rapid pace at which new tools and models are evolving in contrast with the slow pace at which regulatory structures change. Nonetheless, there are opportunities for environmental scientists and policymakers alike to take an impactful role in the ongoing development and implementation of the NRC vision. Six specific areas for scientific coordination and/or policy engagement are identified.
ID 21253
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=21253
Villeneuve, D.L., Coady, K., Escher, B.I., Mihaich, E., Murphy, C., Schlekat, T., Garcia-Reyero, N. (2019):
High‐throughput screening and environmental risk assessment: State of the science and emerging applications
Environ. Toxicol. Chem. 38 (1), 12 - 26