Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1002/cctc.201801262
Volltext Shareable Link
Titel (primär) In situ O2 generation for biocatalytic oxyfunctionalization reactions
Autor Hoschek, A.; Schmid, A.; Bühler, B.
Quelle ChemCatChem
Erscheinungsjahr 2018
Department SOMA
Band/Volume 10
Heft 23
Seite von 5366
Seite bis 5371
Sprache englisch
Keywords Biocatalysis; Oxyfunctionalization; Oxygen mass transfer; Photosynthesis; Water oxidation
Abstract O2‐dependent whole‐cell bioprocesses, such as C−H oxyfunctionalizations, are constrained by technically limited O2 mass transfer and biocatalyst‐inherent O2 respiration. In large‐scale bioprocesses, this restricts the maximum achievable productivity to 5.6 gproduct L−1 h−1 assuming a resting cell concentration of 9.4 gCDW L−1. This concept paper discusses strategies to enhance the O2 availability for biocatalytic oxyfunctionalizations with a focus on the in situ generation of O2 from water. This promising approach was addressed recently by the exploitation of microbial photosynthesis for light‐driven C−H oxyfunctionalization. Via intracellular O2 evolution, phototrophic biocatalysts increase the maximum achievable productivity well beyond technical boundaries. This fundamental advantage over O2‐respiring biocatalysts now awaits scale‐up evaluations, combining established cultivation technologies for phototrophic organisms with bioprocessing techniques for heterotrophic organisms.
dauerhafte UFZ-Verlinkung
Hoschek, A., Schmid, A., Bühler, B. (2018):
In situ O2 generation for biocatalytic oxyfunctionalization reactions
ChemCatChem 10 (23), 5366 - 5371 10.1002/cctc.201801262