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Titel (primär) Effect-based and chemical analytical methods to monitor estrogens under the European Water Framework Directive
Autor Könemann, S.; Kase, R.; Simon, F.; Swart, K.; Buchinger, S.; Schlüsener, M.; Hollert, H.; Escher, B.I.; Werner, I.; Aït-Aïssa, S.; Vermeirssen, E.; Dulio, V.; Valsecchi, S.; Polesello, S.; Behnisch, P.; Javurkova, B.; Perceval, O.; Di Paolo, C.; Olbrich, D.; Sychrova, E.; Schlichting, R.; Leborgne, L.; Clara, M.; Scheffknecht, C.; Marneffe, Y.; Chalon, C.; Tušil, P.; Soldàn, P.; von Danwitz, B.; Schwaiger, J.; San Martín Becares, M.I.; Bersani, F.; Hilscherová, K.; Reifferscheid, G.; Ternes, T.; Carere, M.;
Journal / Serie TrAC-Trends in Analytical Chemistry
Erscheinungsjahr 2018
Department ZELLTOX;
Band/Volume 102
Sprache englisch;
POF III (gesamt) T42;
Keywords Science-policy interface; Estrogen screening; Endocrine disruption; Surface and waste water assessment; Emerging pollutants; EU watch-list; Steroid analyses; In vitro bioassays; Integrated effects of mixtures
Abstract The European Decision EU 2015/495 included three steroidal estrogens, estrone, 17β-estradiol and 17α-ethinyl estradiol, in the “watch-list” of the Water Framework Directive (WFD). As consequence, these substances have to be chemically monitored at the level of their environmental quality standards, which can be challenging. This project aimed to identify reliable effect-based methods (EBMs) for screening of endocrine disrupting compounds, to harmonise monitoring and data interpretation methods, and to contribute to the current WFD review process. Water and wastewater samples were collected across Europe and analysed using chemical analyses and EBMs. The results showed that 17β-estradiol equivalents were comparable among methods, while results can vary between methods based on the relative potencies for individual substances. Further, derived 17β-estradiol equivalents were highly correlated with LC-MS/MS analyses. This study shows that the inclusion of effect-based screening methods into monitoring programmes for estrogens in surface waterbodies would be a valuable complement to chemical analysis.
ID 20664
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=20664
Könemann, S., Kase, R., Simon, F., Swart, K., Buchinger, S., Schlüsener, M., Hollert, H., Escher, B.I., Werner, I., Aït-Aïssa, S., Vermeirssen, E., Dulio, V., Valsecchi, S., Polesello, S., Behnisch, P., Javurkova, B., Perceval, O., Di Paolo, C., Olbrich, D., Sychrova, E., Schlichting, R., Leborgne, L., Clara, M., Scheffknecht, C., Marneffe, Y., Chalon, C., Tušil, P., Soldàn, P., von Danwitz, B., Schwaiger, J., San Martín Becares, M.I., Bersani, F., Hilscherová, K., Reifferscheid, G., Ternes, T., Carere, M. (2018):
Effect-based and chemical analytical methods to monitor estrogens under the European Water Framework Directive
Trac-Trends Anal. Chem. 102 , 225 - 235