Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1111/all.13312 |
Lizenz  |
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| Titel (primär) | The sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALL |
| Autor | Keller, T.; Hohmann, C.; Standl, M.; Wijga, A.H.; Gehring, U.; Melén, E.; Almqvist, C.; Lau, S.; Eller, E.; Wahn, U.; Christiansen, E.S.; von Berg, A.; Heinrich, J.; Lehmann, I.; Maier, D.; Postma, D.S.; Antó, J.M.; Bousquet, J.; Keil, T.; Roll, S. |
| Quelle | Allergy |
| Erscheinungsjahr | 2018 |
| Department | IMMU |
| Band/Volume | 73 |
| Heft | 3 |
| Seite von | 602 |
| Seite bis | 614 |
| Sprache | englisch |
| Supplements | https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fall.13312&attachmentId=2189154159 |
| Keywords | allergic multimorbidity; asthma; birth cohort; puberty; rhinitis |
| UFZ Querschnittsthemen | RU3; |
| Abstract | BackgroundCross-sectional studies suggested that allergy prevalence in
childhood is higher in boys compared to girls, but it remains unclear
whether this inequality changes after puberty. We examined the
sex-specific prevalence of asthma and rhinitis as single and as
multimorbid diseases before and after puberty onset in longitudinal
cohort data.
MethodsIn six European population-based birth cohorts of MeDALL, we assessed the outcomes: current rhinitis, current asthma, current allergic multimorbidity (ie, concurrent asthma and rhinitis), puberty status and allergic sensitization by specific serum antibodies (immunoglobulin E) against aero-allergens. With generalized estimating equations, we analysed the effects of sex, age, puberty (yes/no) and possible confounders on the prevalence of asthma and rhinitis, and allergic multimorbidity in each cohort separately and performed individual participant data meta-analysis. FindingsWe included data from 19013 participants from birth to age 14-20years. Current rhinitis only affected girls less often than boys before and after puberty onset: adjusted odds ratio for females vs males 0.79 (95%-confidence interval 0.73-0.86) and 0.86 (0.79-0.94), respectively (sex-puberty interaction P=.089). Similarly, for current asthma only, females were less often affected than boys both before and after puberty onset: 0.71, 0.63-0.81 and 0.81, 0.64-1.02, respectively (sex-puberty interaction P=.327). The prevalence of allergic multimorbidity showed the strongest sex effect before puberty onset (female-male-OR 0.55, 0.46-0.64) and a considerable shift towards a sex-balanced prevalence after puberty onset (0.89, 0.74-1.04); sex-puberty interaction: P<.001. InterpretationThe male predominance in prevalence before puberty and the sex-shift towards females after puberty onset were strongest in multimorbid patients who had asthma and rhinitis concurrently. |
| dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=20006 |
| Keller, T., Hohmann, C., Standl, M., Wijga, A.H., Gehring, U., Melén, E., Almqvist, C., Lau, S., Eller, E., Wahn, U., Christiansen, E.S., von Berg, A., Heinrich, J., Lehmann, I., Maier, D., Postma, D.S., Antó, J.M., Bousquet, J., Keil, T., Roll, S. (2018): The sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALL Allergy 73 (3), 602 - 614 10.1111/all.13312 |
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