Details zur Publikation
|DOI / URL||Link|
|Titel (primär)||The sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALL|
|Autor||Keller, T.; Hohmann, C.; Standl, M.; Wijga, A.H.; Gehring, U.; Melén, E.; Almqvist, C.; Lau, S.; Eller, E.; Wahn, U.; Christiansen, E.S.; von Berg, A.; Heinrich, J.; Lehmann, I.; Maier, D.; Postma, D.S.; Antó, J.M.; Bousquet, J.; Keil, T.; Roll, S.;|
|Journal / Serie||Allergy|
|POF III (gesamt)||F11;|
|Keywords||allergic multimorbidity; asthma; birth cohort; puberty; rhinitis|
|Abstract||BackgroundCross-sectional studies suggested that allergy prevalence in
childhood is higher in boys compared to girls, but it remains unclear
whether this inequality changes after puberty. We examined the
sex-specific prevalence of asthma and rhinitis as single and as
multimorbid diseases before and after puberty onset in longitudinal
MethodsIn six European population-based birth cohorts of MeDALL, we assessed the outcomes: current rhinitis, current asthma, current allergic multimorbidity (ie, concurrent asthma and rhinitis), puberty status and allergic sensitization by specific serum antibodies (immunoglobulin E) against aero-allergens. With generalized estimating equations, we analysed the effects of sex, age, puberty (yes/no) and possible confounders on the prevalence of asthma and rhinitis, and allergic multimorbidity in each cohort separately and performed individual participant data meta-analysis.
FindingsWe included data from 19013 participants from birth to age 14-20years. Current rhinitis only affected girls less often than boys before and after puberty onset: adjusted odds ratio for females vs males 0.79 (95%-confidence interval 0.73-0.86) and 0.86 (0.79-0.94), respectively (sex-puberty interaction P=.089). Similarly, for current asthma only, females were less often affected than boys both before and after puberty onset: 0.71, 0.63-0.81 and 0.81, 0.64-1.02, respectively (sex-puberty interaction P=.327). The prevalence of allergic multimorbidity showed the strongest sex effect before puberty onset (female-male-OR 0.55, 0.46-0.64) and a considerable shift towards a sex-balanced prevalence after puberty onset (0.89, 0.74-1.04); sex-puberty interaction: P<.001.
InterpretationThe male predominance in prevalence before puberty and the sex-shift towards females after puberty onset were strongest in multimorbid patients who had asthma and rhinitis concurrently.
|Keller, T., Hohmann, C., Standl, M., Wijga, A.H., Gehring, U., Melén, E., Almqvist, C., Lau, S., Eller, E., Wahn, U., Christiansen, E.S., von Berg, A., Heinrich, J., Lehmann, I., Maier, D., Postma, D.S., Antó, J.M., Bousquet, J., Keil, T., Roll, S. (2018):
The sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALL
Allergy 73 (3), 602 - 614