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Titel (primär) Equilibrium biopartitioning of organic anions - A case study for humans and fish
Autor Goss, K.-U.; Bittermann, K.; Henneberger, L.; Linden, L.
Journal / Serie Chemosphere
Erscheinungsjahr 2018
Department AUC; ZELLTOX
Band/Volume 199
Seite von 174
Seite bis 181
Sprache englisch
Keywords Bioaccumulation; Organic anions; Partitioning; Bioconcentration; Risk assessment; Chemical regulation
UFZ Querschnittsthemen RU3;
Abstract In this work we combine partition coefficients between water and membrane lipid, storage lipid, the plasma protein albumin as well as structural protein with the tissue dependent fraction of the respective phases in order to obtain a clearer picture on the relevance of various biological tissues for the bioaccumulation of 31 organic anions. Most of the partition coefficients are based on experimental data, supplemented by some predicted ones. The data suggest that the plasma protein, albumin, will be the major sorption matrix in mammals. Only small fractions of the studied chemicals will occur freely dissolved in an organism. For the investigated acids with pKa <5, partitioning is dominated by the ionic species rather than the corresponding neutral species. Bioconcentration in fish is not expected to occur for many of these acids unless pH in the aqueous environment is low or specific sorption mechanisms are relevant. In contrast, biomagnification in terrestrial mammals would be expected for most organic anions if they are not sufficiently metabolized. We conclude that sorption is important for the toxicokinetics of ionizable organic chemicals and the dominating sorbing matrices are quite different from those for neutral species.
dauerhafte UFZ-Verlinkung
Goss, K.-U., Bittermann, K., Henneberger, L., Linden, L. (2018):
Equilibrium biopartitioning of organic anions - A case study for humans and fish
Chemosphere 199 , 174 - 181