Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Modelling oral up-take of hydrophobic and super-hydrophobic chemicals in fish
Autor Larisch, W.; Goss, K.-U.;
Journal / Serie Environmental Science-Processes & Impacts
Erscheinungsjahr 2018
Department AUC;
Band/Volume 20
Heft 1
Sprache englisch;
POF III (gesamt) T42;
Supplements http://www.rsc.org/suppdata/c7/em/c7em00495h/c7em00495h1.xlsx
http://www.rsc.org/suppdata/c7/em/c7em00495h/c7em00495h2.xlsx
http://www.rsc.org/suppdata/c7/em/c7em00495h/c7em00495h3.pdf
UFZ Querschnittsthemen RU3;
Abstract We have extended a recently published toxicokinetic model for fish (TK-fish) towards the oral up-take of contaminants. Validation with hydrophobic chemicals revealed that diffusive transport through aqueous boundary layers in the gastro-intestinal tract and in the blood is the limiting process. This process can only be modelled correctly if facilitated transport by albumin or bile micelles through these boundary layers is accounted for. In a case study we have investigated the up-take of a super hydrophobic chemical, Dechlorane Plus. Our results suggest that there is no indication of a hydrophobicity or size cut-off in the bioconcentration of this chemical. Based on an extremely high, but mechanistically sound facilitation factor we received model results in good agreement with experimental values from the literature. The results also indicate that established experimental procedures for BCF determination cannot cover the very slow up-take and clearance kinetics that are to be expected for such a chemical.
ID 19840
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=19840
Larisch, W., Goss, K.-U. (2018):
Modelling oral up-take of hydrophobic and super-hydrophobic chemicals in fish
Environ. Sci.-Proc. Imp. 20 (1), 98 - 104