Details zur Publikation |
Kategorie | Textpublikation |
Referenztyp | Zeitschriften |
DOI | 10.1016/j.impact.2017.10.003 |
Titel (primär) | Grouping concept for metal and metal oxide nanomaterials with regard to their ecotoxicological effects on algae, daphnids and fish embryos |
Autor | Hund-Rinke, K.; Schlich, K.; Kühnel, D.; Hellack, B.; Kaminski, H.; Nickel, C. |
Quelle | NanoImpact |
Erscheinungsjahr | 2018 |
Department | BIOTOX |
Band/Volume | 9 |
Seite von | 52 |
Seite bis | 60 |
Sprache | englisch |
Supplements | https://ars.els-cdn.com/content/image/1-s2.0-S2452074817301131-mmc1.docx |
Keywords | Grouping concept; Read-across; Aquatic ecotoxicity; Nanomaterials; Risk assessment |
UFZ Querschnittsthemen | RU3; |
Abstract | Manufactured nanomaterials
(NMs) are being developed in many different variations such as size,
shape, crystalline structure and surface modifications. To avoid the
testing of each single nanomaterial variation, grouping and read-across
strategies for nanomaterials similar to classical chemicals are
discussed. Grouping and read-across aim to identify NM groups with
analogous sets of properties or properties that enable reasonable
predictions of a NM hazard without additional testing. This will
contribute to save costs and time in the risk assessment. So far the
knowledge is still limited how modifications of NMs and their properties
affect ecotoxicity. This study was initiated to support the discussions on grouping regarding aquatic ecotoxicological effects and for the identification of relevant properties as well as the development of a grouping concept addressing aquatic ecotoxicity. A comprehensive and homogenous data set based on fourteen nanomaterials was established. The selected NMs were modifications of five chemical species (Ag, ZnO, TiO2, CeO2, Cu). As the focus was on the applicability for regulatory purposes, for ecotoxicity the OECD test guidelines 201 (algae), 202 (daphnids) and 236 (fish embryo) were considered. The physico-chemical properties of the chosen NMs were determined in deionized water and the test media applied for the ecotoxicological tests. Reactivity, ion release, morphology and ecotoxicity of the chemical composition (information from the bulk material) were identified as the most relevant grouping properties regarding nanomaterial's ecotoxicity. A grouping scheme and procedure was proposed considering these properties. The scheme was validated with a set of additional nanomaterials (TiO2, SiO2, Fe2O3). A rough, but reliable grouping of NMs with different chemical composition was possible. The separation of NMs with the same chemical composition, into different groups was only feasible, if the NMs show major differences in one of the relevant properties (e.g. different shape). Based on the available data set it is unknown whether either further physico-chemical properties have to be considered or whether the impact of the selected variations on ecotoxicity is too minor to result in significant ecotoxicological differences. In order to further advance the grouping concept for regulatory testing, future developments should include the specification of threshold values with regard to the properties solubility and reactivity as well as for the characterization of the morphology. Additionally, test methods addressing the sorption tendency of NMs to algae could contribute to an improvement of the ecotox-scheme with regard to the consideration of physical effects by shading resulting in limited growth. |
dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=19612 |
Hund-Rinke, K., Schlich, K., Kühnel, D., Hellack, B., Kaminski, H., Nickel, C. (2018): Grouping concept for metal and metal oxide nanomaterials with regard to their ecotoxicological effects on algae, daphnids and fish embryos NanoImpact 9 , 52 - 60 10.1016/j.impact.2017.10.003 |