Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Buchkapitel |
| DOI | 10.1007/978-3-319-47754-1_9 |
| Titel (primär) | An integrated data-driven strategy for safe-by-design nanoparticles: the FP7 MODERN project |
| Titel (sekundär) | Modelling the toxicity of nanoparticles |
| Autor | Brehm, M.; Kafka, A.; Bamler, M.; Kühne, R.
; Schüürmann, G.; Sikk, L.; Burk, J.; Burk, P.; Tamm, T.; Tämm, K.; Pokhrel, S.; Mädler, L.; Kahru, A.; Aruoja, V.; Sihtmäe, M.; Scott-Fordsmand, J.; Sorensen, P.B.; Escorihuela, L.; Roca, C.P.; Fernández, A.; Giralt, F.; Rallo, R. |
| Herausgeber | Tran, L.; Bañares, M.A.; Rallo, R. |
| Quelle | Advances in Experimental Medicine and Biology |
| Erscheinungsjahr | 2017 |
| Department | OEC |
| Band/Volume | 947 |
| Seite von | 257 |
| Seite bis | 301 |
| Sprache | englisch |
| Keywords | Nanotoxicology; Nanoinformatics; Nanodescriptors; QNAR; Risk assessment |
| UFZ Querschnittsthemen | RU3; |
| Abstract | The development and implementation of safe-by-design strategies is key for the safe development of future generations of nanotechnology enabled products. The safety testing of the huge variety of nanomaterials that can be synthetized is unfeasible due to time and cost constraints. Computational modeling facilitates the implementation of alternative testing strategies in a time and cost effective way. The development of predictive nanotoxicology models requires the use of high quality experimental data on the structure, physicochemical properties and bioactivity of nanomaterials. The FP7 Project MODERN has developed and evaluated the main components of a computational framework for the evaluation of the environmental and health impacts of nanoparticles. This chapter describes each of the elements of the framework including aspects related to data generation, management and integration; development of nanodescriptors; establishment of nanostructure-activity relationships; identification of nanoparticle categories; hazard ranking and risk assessment. |
| dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=19461 |
| Brehm, M., Kafka, A., Bamler, M., Kühne, R., Schüürmann, G., Sikk, L., Burk, J., Burk, P., Tamm, T., Tämm, K., Pokhrel, S., Mädler, L., Kahru, A., Aruoja, V., Sihtmäe, M., Scott-Fordsmand, J., Sorensen, P.B., Escorihuela, L., Roca, C.P., Fernández, A., Giralt, F., Rallo, R. (2017): An integrated data-driven strategy for safe-by-design nanoparticles: the FP7 MODERN project In: Tran, L., Bañares, M.A., Rallo, R. (eds.) Modelling the toxicity of nanoparticles Adv. Exp. Med. Biol. 947 Springer, Berlin, p. 257 - 301 10.1007/978-3-319-47754-1_9 |
|