Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1093/femsre/fux044
Titel (primär) Beyond the bulk: disclosing the life of single microbial cells
Autor Rosenthal, K.; Oehling, V.; Dusny, C.; Schmid, A.
Journal / Serie FEMS Microbiology Reviews
Erscheinungsjahr 2017
Department SOMA
Band/Volume 41
Heft 6
Seite von 751
Seite bis 780
Sprache englisch
Keywords single cell analysis; heterogeneity; single cell dynamics; microfluidics; technical bias; lab-on-a-chip
UFZ Querschnittsthemen RU4;
Abstract Microbial single cell analysis has led to discoveries that are beyond what can be resolved with population-based studies. It provides a pristine view of the mechanisms that organize cellular physiology, unbiased by population heterogeneity or uncontrollable environmental impacts. A holistic description of cellular functions at the single cell level requires analytical concepts beyond the miniaturization of existing technologies, defined but uncontrolled by the biological system itself. This review provides an overview of the latest advances in single cell technologies and demonstrates their potential. Opportunities and limitations of single cell microbiology are discussed using selected application-related examples.
dauerhafte UFZ-Verlinkung
Rosenthal, K., Oehling, V., Dusny, C., Schmid, A. (2017):
Beyond the bulk: disclosing the life of single microbial cells
FEMS Microbiol. Rev. 41 (6), 751 - 780