Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) The challenge of the application of 'omics technologies in chemicals risk assessment: Background and outlook
Autor Sauer, U.G.; Deferme, L.; Gribaldo, L.; Hackermüller, J.; Tralau, T.; van Ravenzwaay, B.; Yauk, C.; Poole, C.; Tong, W.; Gant, T.W.;
Journal / Serie Regulatory Toxicology and Pharmacology
Erscheinungsjahr 2017
Department MOLSYB;
Band/Volume 91
Heft Suppl. 1
Sprache englisch;
POF III (gesamt) T42; F11;
Supplements https://ars.els-cdn.com/content/image/1-s2.0-S0273230017302921-mmc1.docx
Keywords Omics; Transcriptomics; Weight-of-evidence; Registration, Evaluation, Authorisation, and Restriction (REACH); Plant protection products; Regulatory toxicology; Hazard assessment; Test method validation; Test method standardisation
UFZ Querschnittsthemen RU3;
Abstract This survey by the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) highlights that ‘omics technologies are generally not yet applied to meet standard information requirements during regulatory hazard assessment. While they are used within weight-of-evidence approaches to investigate substances’ modes-of-action, consistent approaches for the generation, processing and interpretation of ‘omics data are not applied. To date, no ‘omics technology has been standardised or validated. Best practices for performing ‘omics studies for regulatory purposes (e.g., microarrays for transcriptome profiling) remain to be established. Therefore, three frameworks for (i) establishing a Good-Laboratory Practice-like context for collecting, storing and curating ‘omics data; (ii) ‘omics data processing; and (iii) quantitative WoE approaches to interpret ‘omics data have been developed, that are presented in this journal issue. Application of the frameworks will enable between-study comparison of results, which will facilitate the regulatory applicability of 'omics data. The frameworks do not constitute prescriptive protocols precluding any other data analysis method, but provide a baseline for analysis that can be applied to all data allowing ready cross-comparison. Data analysis that does not follow the frameworks can be justified and the resulting data can be compared with the Framework-based common analysis output.
ID 19238
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=19238
Sauer, U.G., Deferme, L., Gribaldo, L., Hackermüller, J., Tralau, T., van Ravenzwaay, B., Yauk, C., Poole, C., Tong, W., Gant, T.W. (2017):
The challenge of the application of 'omics technologies in chemicals risk assessment: Background and outlook
Regul. Toxicol. Pharmacol. 91 (Suppl. 1), S14 - S26