Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1038/s41598-017-08348-5 |
| Titel (primär) | STAT3-induced long noncoding RNAs in multiple myeloma cells display different properties in cancer |
| Autor | Binder, S.; Hösler, N.; Riedel, D.; Zipfel, I.; Buschmann, T.; Kämpf, C.; Reiche, K.; Burger, R.; Gramatzki, M.; Hackermüller, J.
; Stadler, P.F.; Horn, F. |
| Quelle | Scientific Reports |
| Erscheinungsjahr | 2017 |
| Department | MOLSYB |
| Band/Volume | 7 |
| Seite von | art. 7976 |
| Sprache | englisch |
| Supplements | https://static-content.springer.com/esm/art%3A10.1038%2Fs41598-017-08348-5/MediaObjects/41598_2017_8348_MOESM1_ESM.pdf |
| UFZ Querschnittsthemen | RU3; |
| Abstract | Interleukin-6 (IL-6)-activated Signal Transducer and Activator of Transcription 3 (STAT3) facilitates survival in the multiple myeloma cell line INA-6 and therefore represents an oncogenic key player. However, the biological mechanisms are still not fully understood. In previous studies we identified microRNA-21 as a STAT3 target gene with strong anti-apoptotic potential, suggesting that noncoding RNAs have an impact on the pathogenesis of human multiple myeloma. Here, we describe five long noncoding RNAs (lncRNAs) induced by IL-6-activated STAT3, which we named STAiRs. While STAiRs 1, 2 and 6 remain unprocessed in the nucleus and show myeloma-specific expression, STAiRs 15 and 18 are spliced and broadly expressed. Especially STAiR2 and STAiR18 are promising candidates. STAiR2 originates from the first intron of a tumor suppressor gene. Our data support a mutually exclusive expression of either STAiR2 or the functional tumor suppressor in INA-6 cells and thus a contribution of STAiR2 to tumorigenesis. Furthermore, STAiR18 was shown to be overexpressed in every tested tumor entity, indicating its global role in tumor pathogenesis. Taken together, our study reveals a number of STAT3-induced lncRNAs suggesting that the interplay between the coding and noncoding worlds represents a fundamental principle of STAT3-driven cancer development in multiple myeloma and beyond. |
| dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=19111 |
| Binder, S., Hösler, N., Riedel, D., Zipfel, I., Buschmann, T., Kämpf, C., Reiche, K., Burger, R., Gramatzki, M., Hackermüller, J., Stadler, P.F., Horn, F. (2017): STAT3-induced long noncoding RNAs in multiple myeloma cells display different properties in cancer Sci. Rep. 7 , art. 7976 10.1038/s41598-017-08348-5 |
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