Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1002/biot.201600549
Volltext Shareable Link
Titel (primär) Taking control over microbial populations: Current approaches for exploiting biological noise in bioprocesses
Autor Delvigne, F.; Baert, J.; Sassi, H.; Fickers, P.; Grünberger, A.; Dusny, C.
Journal / Serie Biotechnology Journal
Erscheinungsjahr 2017
Department SOMA
Band/Volume 12
Heft 7
Seite von art. 1600549
Sprache englisch
UFZ Querschnittsthemen RU4;

Phenotypic plasticity of microbial cells has attracted much attention and several research efforts have been dedicated to the description of methods aiming at characterizing phenotypic heterogeneity and its impact on microbial populations. However, different approaches have also been suggested in order to take benefit from noise in a bioprocess perspective, e.g. by increasing the robustness or productivity of a microbial population. This review is dedicated to outline these controlling methods. A common issue, that has still to be addressed, is the experimental identification and the mathematical expression of noise. Indeed, the effective interfacing of microbial physiology with external parameters that can be used for controlling physiology depends on the acquisition of reliable signals. Latest technologies, like single cell microfluidics and advanced flow cytometric approaches, enable linking physiology, noise, heterogeneity in productive microbes with environmental cues and hence allow correctly mapping and predicting biological behavior via mathematical representations. However, like in the field of electronics, signals are perpetually subjected to noise. If appropriately interpreted, this noise can give an additional insight into the behavior of the individual cells within a microbial population of interest. This review focuses on recent progress made at describing, treating and exploiting biological noise in the context of microbial populations used in various bioprocess applications.

dauerhafte UFZ-Verlinkung
Delvigne, F., Baert, J., Sassi, H., Fickers, P., Grünberger, A., Dusny, C. (2017):
Taking control over microbial populations: Current approaches for exploiting biological noise in bioprocesses
Biotechnol. J. 12 (7), art. 1600549