Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Association of atopic dermatitis with cardiovascular risk factors and diseases
Autor Standl, M.; Tesch, F.; Baurecht, H.; Rodríguez, E.; Müller-Nurasyid, M.; Gieger, C.; Peters, A.; Wang-Sattler, R.; Prehn, C.; Adamski, J.; Kronenberg, F.; Schulz, H.; Koletzko, S.; Schikowski, T.; von Berg, A.; Lehmann, I.; Berdel, D.; Heinrich, J.; Schmitt, J.; Weidinger, S.;
Journal / Serie Journal of Investigative Dermatology
Erscheinungsjahr 2017
Department IMMU;
Band/Volume 137
Heft 5
Sprache englisch;
POF III (gesamt) F11;
UFZ Querschnittsthemen RU3;
Abstract Epidemiological studies suggested an association between atopic dermatitis (AD) and cardiovascular disease (CVD). Therefore, we investigate associations and potential underlying pathways of AD and CVD in large cohort studies: the AOK PLUS cohort (n=1.2Mio), the GINIplus/LISAplus birth cohorts (n=2286), and the KORA F4 cohort (n=2990). Additionally, metabolomics in KORA F4 and established cardiovascular risk loci in genome-wide data on 10,788 AD cases and 30,047 controls were analyzed. Longitudinal analysis of AD patients in AOK PLUS showed slightly increased risk for incident angina pectoris (AP) (adjusted risk ratio 1.17; 95%-confidence interval 1.12-1.23), hypertension (1.04 (1.02-1.06)) and peripheral arterial disease (PAD) (1.15 (1.11-1.19)) but not for myocardial infarction (MI) (1.05 (0.99-1.12) and stroke (1.02 (0.98-1.07)). In KORA F4 and GINIplus/LISAplus, AD was not associated with cardiovascular risk factors (CVRFs) and no differences in metabolite levels were detected. There was no robust evidence for shared genetic risk variants of AD and CVD. This study indicates only a marginally increased risk for AP, hypertension and PAD and no increased risk for MI or stroke in AD patients. Relevant associations of AD with CVRFs reported in US-populations could not be confirmed. Likewise, AD patients did not have increased genetic risk factors for CVD.
ID 18517
dauerhafte UFZ-Verlinkung
Standl, M., Tesch, F., Baurecht, H., Rodríguez, E., Müller-Nurasyid, M., Gieger, C., Peters, A., Wang-Sattler, R., Prehn, C., Adamski, J., Kronenberg, F., Schulz, H., Koletzko, S., Schikowski, T., von Berg, A., Lehmann, I., Berdel, D., Heinrich, J., Schmitt, J., Weidinger, S. (2017):
Association of atopic dermatitis with cardiovascular risk factors and diseases
J. Invest. Dermatol. 137 (5), 1074 - 1081