Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Corrigendum: The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons (vol 48, pg 427, 2016). Corrected after print 25 April 2016
Autor Fontenot, Q.; Ferrara, A.; Searle, S.M.J.; Aken, B.; Yandell, M.; Schneider, I.; Yoder, J.A.; Volff, J.-N.; Meyer, A.; Amemiya, C.T.; Venkatesh, B.; Holland, P.W.H.; Guiguen, Y.; Bobe, J.; Shubin, N.H.; Di Palma, F.; Alföldi, J.; Lindblad-Toh, K.; Postlethwait, J.H.; Martin, K.J.; Mulley, J.F.; Ravi, V.; Lee, A.P.; Nakamura, T.; Chalopin, D.; Fan, S.; Wcisel, D.; Cañestro, C.; Sydes, J.; Beaudry, F.E.G.; Sun, Y.; Hertel, J.; Beam, M.J.; Fasold, M.; Ishiyama, M.; Johnson, J.; Kehr, S.; Lara, M.; Letaw, J.H.; Litman, G.W.; Litman, R.T.; Mikami, M.; Ota, T.; Saha, N.R.; Williams, L.; Stadler, P.F.; Wang, H.; Taylor, J.S.; Braasch, I.; Gehrke, A.R.; Smith, J.J.; Kawasaki, K.; Manousaki, T.; Pasquier, J.; Amores, A.; Desvignes, T.; Batzel, P.; Catchen, J.; Berlin, A.M.; Campbell, M.S.; Barrell, D.
Journal / Serie Nature Genetics
Erscheinungsjahr 2016
Department MOLSYB
Band/Volume 48
Heft 6
Seite von 700
Seite bis 700
Sprache englisch
UFZ Querschnittsthemen RU3;
Abstract To connect human biology to fish biomedical models, we sequenced the genome of spotted gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome duplication (TGD). The slowly evolving gar genome has conserved in content and size many entire chromosomes from bony vertebrate ancestors. Gar bridges teleosts to tetrapods by illuminating the evolution of immunity, mineralization and development (mediated, for example, by Hox, ParaHox and microRNA genes). Numerous conserved noncoding elements (CNEs; often cis regulatory) undetectable in direct human-teleost comparisons become apparent using gar: functional studies uncovered conserved roles for such cryptic CNEs, facilitating annotation of sequences identified in human genome-wide association studies. Transcriptomic analyses showed that the sums of expression domains and expression levels for duplicated teleost genes often approximate the patterns and levels of expression for gar genes, consistent with subfunctionalization. The gar genome provides a resource for understanding evolution after genome duplication, the origin of vertebrate genomes and the function of human regulatory sequences.
dauerhafte UFZ-Verlinkung
Fontenot, Q., Ferrara, A., Searle, S.M.J., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.-N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W.H., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E.G., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D. (2016):
Corrigendum: The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons (vol 48, pg 427, 2016). Corrected after print 25 April 2016
Nature Genet. 48 (6), 700 - 700