Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Inhalation TTC values: A new integrative grouping approach considering structural, toxicological and mechanistic features
Autor Tluczkiewicz, I.; Kühne, R.; Ebert, R.-U.; Batke, M.; Schüürmann, G.; Mangelsdorf, I.; Escher, S.E.;
Journal / Serie Regulatory Toxicology and Pharmacology
Erscheinungsjahr 2016
Department OEC;
Band/Volume 78
Sprache englisch;
POF III (gesamt) T42;
Keywords TTC; Threshold of toxicological concern; Inhalation exposure; Repeated dose; Grouping; Local effects; Toxicity
UFZ Querschnittsthemen RU3;
Abstract

The present publication describes an integrative grouping concept to derive threshold values for inhalation exposure. The classification scheme starts with differences in toxicological potency and develops criteria to group compounds into two potency classes, namely toxic (T-group) or low toxic (L-group).

The TTC concept for inhalation exposure is based on the TTC RepDose data set, consisting of 296 organic compounds with 608 repeated-dose inhalation studies. Initially, 21 structural features (SFs) were identified as being characteristic for compounds of either high or low NOEC values (Schüürmann et al., 2016). In subsequent analyses these SF groups were further refined by taking into account structural homogeneity, type of toxicological effect observed, differences in absorption, metabolism and mechanism of action (MoA), to better define their structural and toxicological boundaries. Differentiation of a local or systemic mode of action did not improve the classification scheme.

Finally, 28 groups were discriminated: 19 T-groups and 9 L-groups. Clearly distinct thresholds were derived for the T- and L-toxicity groups, being 2 × 10−5 ppm (2 μg/person/day) and 0.05 ppm (4260 μg/person/day), respectively. The derived thresholds and the classification are compared to the initial mainly structure driven grouping (Schüürmann et al., 2016) and to the Cramer classification.

ID 17614
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=17614
Tluczkiewicz, I., Kühne, R., Ebert, R.-U., Batke, M., Schüürmann, G., Mangelsdorf, I., Escher, S.E. (2016):
Inhalation TTC values: A new integrative grouping approach considering structural, toxicological and mechanistic features
Regul. Toxicol. Pharmacol. 78 , 8 - 23