Details zur Publikation

Referenztyp Buchkapitel
DOI / URL Link
Titel (primär) High-resolution mass spectrometry in the effect-directed analysis of water resources
Titel (sekundär) Applications of time-of-flight and orbitrap mass spectrometry in environmental, food, doping, and forensic analysis
Autor Krauss, M.;
Herausgeber Pérez, S.; Eichhorn, P.; Barceló, D.;
Journal / Serie Comprehensive Analytical Chemistry
Erscheinungsjahr 2016
Department WANA;
Band/Volume 71
Sprache englisch;
POF III (gesamt) T32;
UFZ Querschnittsthemen RU2;
Abstract Effect-directed analysis (EDA) is an approach to identify chemicals in complex mixtures which exert adverse effects. To this end, a combination of bioassays for effect detection, fractionation to reduce sample complexity, and chemical analysis mainly by liquid or gas chromatography coupled to mass spectrometry is used. High-resolution mass spectrometry (HRMS) using orbitrap or time-of-flight analysers has become a key technique for EDA, as it allows for an equally sensitive and selective analysis of samples without a pre-definition of the compounds of interest. This chapter provides an overview on the state of the art of HRMS in EDA studies on water and sediment. The main HRMS-based strategies such as target screening, screening for suspected toxicants, library search, and true unknown identification are presented, highlighting the way these were used in different studies including their strengths and current limitations.
ID 17574
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=17574
Krauss, M. (2016):
High-resolution mass spectrometry in the effect-directed analysis of water resources
In: Pérez, S., Eichhorn, P., Barceló, D. (eds.)
Applications of time-of-flight and orbitrap mass spectrometry in environmental, food, doping, and forensic analysis
Comprehensive Analytical Chemistry 71
Elsevier, Amsterdam, p. 433 - 457