Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1016/j.eurpolymj.2016.01.006 |
| Titel (primär) | Functional micelles formed by branched polymeric surfactants: synthesis, characteristics, and application as nanoreactors and carriers |
| Autor | Riabtseva, A.; Mitina, N.; Grytsyna, I.; Boiko, N.; Garamus, V.M.; Stryhanyuk, H.; Stoika, R.; Zaichenko, A. |
| Quelle | European Polymer Journal |
| Erscheinungsjahr | 2016 |
| Department | ISOBIO |
| Band/Volume | 75 |
| Seite von | 406 |
| Seite bis | 422 |
| Sprache | englisch |
| Keywords | Branched polymer; Micelles; Carriers; Maghemite particles; Tumor cells; Engulfment |
| UFZ Querschnittsthemen | RU3; ProVIS; |
| Abstract | Branched polymeric surfactants composed of grafted non-ionic polyethylene glycol (PEG) and anionic polyelectrolyte chains were synthesized via radical polymerization initiated by the comb-like PEG-containing polyperoxide. Above definite concentration in solution, these surfactants form micelle-like structures (MLS). The MLS formed by branched polymeric molecules are of larger size in comparison with size of MLS formed by the initial PEG-containing polyperoxide that is caused mainly by different mechanism of their self-organization and morphology of formed MLS. The availability of grafted polyelectrolyte chains in the MLS provides a possibility of their use as the containers for immobilization of bio-active substances and nucleation of the inorganic nanoparticles, as well as formation of their stable colloidal systems in water in a wide pH range. Noticeable compaction and narrowed size distribution of the MLS were revealed after immobilization of doxorubicin (Dox) molecules or Fe2O3 nanocrystals. MLS-based systems were used for delivery of Dox and maghemite particles at treatment of tumor cells. Both MLS-based formulations of Dox and Fe2O3 were efficiently engulfed by rat glioma C6 cells. A significant (10 times) decrease in the effective therapeutic dose of Dox was found when this drug was delivered by a MLS-based formulation of Dox. That effect might be explained by a specific structure and functionality of the novel carrier used for immobilization of drug that should be delivered to target cells. |
| Riabtseva, A., Mitina, N., Grytsyna, I., Boiko, N., Garamus, V.M., Stryhanyuk, H., Stoika, R., Zaichenko, A. (2016): Functional micelles formed by branched polymeric surfactants: synthesis, characteristics, and application as nanoreactors and carriers Eur. Polym. J. 75 , 406 - 422 10.1016/j.eurpolymj.2016.01.006 |
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