Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1016/j.jcis.2016.01.032 |
| Titel (primär) | Exploring 3D structural influences of aliphatic and aromatic chemicals on α-cyclodextrin binding |
| Autor | Linden, L.; Goss, K.-U.; Endo, S. |
| Quelle | Journal of Colloid and Interface Science |
| Erscheinungsjahr | 2016 |
| Department | AUC |
| Band/Volume | 468 |
| Seite von | 42 |
| Seite bis | 50 |
| Sprache | englisch |
| Keywords | α-Cyclodextrin (CD); Steric effect; Binding constant; Inclusion complex; Cyclodextrin water partitioning; Solute 3D structure |
| UFZ Querschnittsthemen | RU3; |
| Abstract | Binding of solutes to macromolecules is often influenced by steric effects caused by the 3D structures of both binding partners. In this study, the 1:1 α-cyclodextrin (αCD) binding constants (Ka1) for 70 organic chemicals were determined to explore the solute-structural effects on the αCD binding. Ka1 was measured using a three-part partitioning system with either a headspace or a passive sampler serving as the reference phase. The Ka1 values ranged from 1.08 to 4.97 log units. The results show that longer linear aliphatic chemicals form more stable complexes than shorter ones, and that the position of the functional group has a strong influence on Ka1, even stronger than the type of the functional group. Comparison of linear and variously branched aliphatic chemicals indicates that having a sterically unhindered alkyl chain is favorable for binding. These results suggest that only one alkyl chain can enter the binding cavity. Relatively small aromatic chemicals such as 1,3-dichlorobenzene bind to αCD well, while larger ones like tetrachlorobenzene and 3-ring aromatic chemicals show only a weak interaction with αCD, which can be explained by cavity exclusion. The findings of this study help interpret cyclodextrin binding data and facilitate the understanding of binding processes to macromolecules. |
| dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=17044 |
| Linden, L., Goss, K.-U., Endo, S. (2016): Exploring 3D structural influences of aliphatic and aromatic chemicals on α-cyclodextrin binding J. Colloid Interface Sci. 468 , 42 - 50 10.1016/j.jcis.2016.01.032 |
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