Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1007/s00216-015-9026-2
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Titel (primär) Multi-class method for biomonitoring of hair samples using gas chromatography-mass spectrometry
Autor Martín, J.; Möder, M.; Gaudl, A.; Alonso, E.; Reemtsma, T.
Quelle Analytical and Bioanalytical Chemistry
Erscheinungsjahr 2015
Department ANA
Band/Volume 407
Heft 29
Seite von 8725
Seite bis 8734
Sprache englisch
Keywords Emerging pollutants – Hair analysis – Gas chromatography–mass spectrometry – Human biomonitoring
UFZ Querschnittsthemen RU3;
Abstract Currently, non-invasive biomonitoring of human exposure to organic pollutants bases upon the analysis mainly of urine and human breast milk. While mostly persistent organic pollutants are the center of interest, the aim of our study was to develop a method for the determination of different chemical classes of emerging pollutants (organophosphorus flame retardants, plastic additives such as phthalates, bisphenol A, insecticides, antimicrobials, preservatives and musk fragrances) in hair by gas chromatography–mass spectrometry. The preferred sample preparation included hydrolysis of the hair with trifluoroacetic acid in methanol followed by a liquid–liquid extraction using hexane/ethyl acetate. The validated method is characterized by recoveries higher than 77 % for most analytes, relative standard deviations below 16 % and limits of detection between 2 pg mg−1 (HHCB) and 292 pg mg−1 (propylparaben) using 50 mg of dry hair. After respective blank corrections, bis-(2-ethylhexyl)phthalate (DEHP) and the musk fragrance HHCB were the predominant compounds determined in all hair samples at concentrations between 32 and 59 ng mg−1 and 0.8–13 ng mg−1, respectively. The bactericide triclosan and the insect repellent N,N-diethyl-3-methylbenzamide (DEET) were detected in selected hair samples at 2 and 0.8 ng mg−1, respectively.
dauerhafte UFZ-Verlinkung
Martín, J., Möder, M., Gaudl, A., Alonso, E., Reemtsma, T. (2015):
Multi-class method for biomonitoring of hair samples using gas chromatography-mass spectrometry
Anal. Bioanal. Chem. 407 (29), 8725 - 8734 10.1007/s00216-015-9026-2