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Titel (primär) Multi-class method for biomonitoring of hair samples using gas chromatography-mass spectrometry
Autor Martín, J.; Möder, M.; Gaudl, A.; Alonso, E.; Reemtsma, T.;
Journal / Serie Analytical and Bioanalytical Chemistry
Erscheinungsjahr 2015
Department ANA;
Band/Volume 407
Heft 29
Sprache englisch;
POF III (gesamt) T41;
Supplements https://static-content.springer.com/esm/art%3A10.1007%2Fs00216-015-9026-2/MediaObjects/216_2015_9026_MOESM1_ESM.pdf
Keywords Emerging pollutants – Hair analysis – Gas chromatography–mass spectrometry – Human biomonitoring
UFZ Querschnittsthemen RU3;
Abstract Currently, non-invasive biomonitoring of human exposure to organic pollutants bases upon the analysis mainly of urine and human breast milk. While mostly persistent organic pollutants are the center of interest, the aim of our study was to develop a method for the determination of different chemical classes of emerging pollutants (organophosphorus flame retardants, plastic additives such as phthalates, bisphenol A, insecticides, antimicrobials, preservatives and musk fragrances) in hair by gas chromatography–mass spectrometry. The preferred sample preparation included hydrolysis of the hair with trifluoroacetic acid in methanol followed by a liquid–liquid extraction using hexane/ethyl acetate. The validated method is characterized by recoveries higher than 77 % for most analytes, relative standard deviations below 16 % and limits of detection between 2 pg mg−1 (HHCB) and 292 pg mg−1 (propylparaben) using 50 mg of dry hair. After respective blank corrections, bis-(2-ethylhexyl)phthalate (DEHP) and the musk fragrance HHCB were the predominant compounds determined in all hair samples at concentrations between 32 and 59 ng mg−1 and 0.8–13 ng mg−1, respectively. The bactericide triclosan and the insect repellent N,N-diethyl-3-methylbenzamide (DEET) were detected in selected hair samples at 2 and 0.8 ng mg−1, respectively.
ID 16905
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=16905
Martín, J., Möder, M., Gaudl, A., Alonso, E., Reemtsma, T. (2015):
Multi-class method for biomonitoring of hair samples using gas chromatography-mass spectrometry
Anal. Bioanal. Chem. 407 (29), 8725 - 8734