Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Linking in vitro effects and detected organic micropollutants in surface water using mixture-toxicity modeling
Autor Neale, P.A.; Ait-Aissa, S.; Brack, W.; Creusot, N.; Denison, M.S.; Deutschmann, B.; Hilscherová, K.; Hollert, H.; Krauss, M.; Novák, J.; Schulze, T.; Seiler, T.-B.; Serra, H.; Shao, Y.; Escher, B.I.;
Journal / Serie Environmental Science & Technology
Erscheinungsjahr 2015
Department WANA; ZELLTOX;
Band/Volume 49
Heft 24
Sprache englisch;
POF III (gesamt) T32;
Supplements https://pubs.acs.org/doi/suppl/10.1021/acs.est.5b04083/suppl_file/es5b04083_si_001.pdf
https://pubs.acs.org/doi/suppl/10.1021/acs.est.5b04083/suppl_file/es5b04083_si_002.xlsx
UFZ Querschnittsthemen RU2;
Abstract Surface water can contain countless organic micropollutants, and targeted chemical analysis alone may only detect a small fraction of the chemicals present. Consequently, bioanalytical tools can be applied complementary to chemical analysis to detect the effect of complex chemical mixtures. In this study, bioassays indicative of activation of the aryl hydrocarbon receptor (AhR), activation of the pregnane X receptor (PXR), activation of the estrogen receptor (ER), adaptive stress responses to oxidative stress (Nrf2), genotoxicity (p53) and inflammation (NF-κB) and fish embryo toxicity were applied along with chemical analysis to water extracts from the Danube River. Mixture toxicity modeling was applied to determine the contribution of detected chemicals to the biological effect. Effect concentrations for between 0 to 13 detected chemicals could be found in the literature for the different bioassays. Detected chemicals explained less than 0.2% of the biological effect in the PXR activation, adaptive stress response and fish embryo toxicity assays, while five chemicals explained up to 80% of ER activation and three chemicals explained up to 71% of AhR activation. This study highlights the importance of fingerprinting the effects of detected chemicals.
ID 16705
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=16705
Neale, P.A., Ait-Aissa, S., Brack, W., Creusot, N., Denison, M.S., Deutschmann, B., Hilscherová, K., Hollert, H., Krauss, M., Novák, J., Schulze, T., Seiler, T.-B., Serra, H., Shao, Y., Escher, B.I. (2015):
Linking in vitro effects and detected organic micropollutants in surface water using mixture-toxicity modeling
Environ. Sci. Technol. 49 (24), 14614 - 14624