Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation
Autor Polte, T.; Petzold, S.; Bertrand, J.; Schütze, N.; Hinz, D.; Simon, J.C.; Lehmann, I.; Echtermeyer, F.; Pap, T.; Averbeck, M.;
Journal / Serie Nature Communications
Erscheinungsjahr 2015
Department IMMU;
Band/Volume 6
Sprache englisch;
POF III (gesamt) F11;
Supplements https://static-content.springer.com/esm/art%3A10.1038%2Fncomms8554/MediaObjects/41467_2015_BFncomms8554_MOESM45_ESM.pdf
UFZ Querschnittsthemen RU3;
Abstract Syndecan-4 (SDC4), expressed on dendritic cells (DCs) and activated T cells, plays a crucial role in DC motility and has been shown as a potential target for activated T-cell-driven diseases. In the present study, we investigate the role of SDC4 in the development of T-helper 2 cell-mediated allergic asthma. Using SDC4-deficient mice or an anti-SDC4 antibody we show that the absence or blocking of SDC4 signalling in ovalbumin-sensitized mice results in a reduced asthma phenotype compared with control animals. Most importantly, even established asthma is significantly decreased using the anti-SDC4 antibody. The disturbed SDC4 signalling leads to an impaired motility and directional migration of antigen-presenting DCs and therefore, to a modified sensitization leading to diminished airway inflammation. Our results demonstrate that SDC4 plays an important role in asthma induction and indicate SDC4 as possible target for therapeutic intervention in this disease.
ID 16346
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=16346
Polte, T., Petzold, S., Bertrand, J., Schütze, N., Hinz, D., Simon, J.C., Lehmann, I., Echtermeyer, F., Pap, T., Averbeck, M. (2015):
Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation
Nat. Commun. 6 , art. 7554