Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1007/BF03194219
Titel (primär) Sequence diversity of MHC class II DRB genes in the bank vole Myodes glareolus
Autor Babik, W.; Radwan, J.
Journal / Serie Acta Theriologica
Erscheinungsjahr 2007
Department BZF
Band/Volume 52
Heft 3
Seite von 227
Seite bis 235
Sprache englisch
Keywords major histocompatibility complex; polymorphism; rodents; selection; recombination
Abstract In recent years, the bank vole Myodes glareolus (Schreber, 1780) has emerged as a model system for parasitological, behavioural and ecological studies and seems ideally suited to address questions concerning the importance of MHC variation at individual and population levels. Here, we provide the first extensive survey of sequence variation in the MHC class II DRB genes in this species. Among 34 analysed voles we found 15 unique sequences, representing most likely two loci, at least one of them expressed. Despite very high overall sequence divergence, particularly in the Antigen Binding Sites (ABS), we detected signatures of positive selection that has been acting on DRB in the bank vole. Phylogenetic analysis demonstrated that the bank vole DRB alleles do not form a monophyletic group but are intermingled with other rodent alleles that is consistent with long-term persistence of ancient allelic lineages maintained through balancing selection. Our sequence data will forward the design of efficient genotyping methods, which will permit testing hypotheses pertaining to the ecological causes and consequences of MHC variation in the bank vole.
dauerhafte UFZ-Verlinkung
Babik, W., Radwan, J. (2007):
Sequence diversity of MHC class II DRB genes in the bank vole Myodes glareolus
Acta Theriol. 52 (3), 227 - 235