Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Integrated Testing Strategies (ITS) for safety assessment
Autor Rovida, C.; Alépée, N.; Api, A.M.; Basketter, D.A.; Bois, F.Y.; Caloni, F.; Corsini, E.; Daneshian, M.; Eskes, C.; Ezendam, J.; Fuchs, H.; Hayden, P.; Hegele-Hartung, C.; Hoffmann, S.; Hubesch, B.; Jacobs, M.N.; Jaworska, J.; Kleensang, A.; Kleinstreuer, N.; Lalko, J.; Landsiedel, R.; Lebreux, F.; Luechtefeld, T.; Locatelli, M.; Mehling, A.; Natsch, A.; Pitchford, J.W.; Prater, D.; Prieto, P.; Schepky, A.; Schüürmann, G.; Smirnova, L.; Toole, C.; van Vliet, E.; Weisensee, D.; Hartung, T.;
Journal / Serie ALTEX - Alternatives to Animal Experimentation
Erscheinungsjahr 2015
Department OEC;
Band/Volume 32
Heft 1
Sprache englisch;
POF III (gesamt) T42;
Keywords in vitro methods, testing strategy, Tox21c, skin sensitization, computational toxicology
UFZ Querschnittsthemen RU3;
Abstract Integrated testing strategies (ITS), as opposed to a single definitive test or fixed batteries of tests, are expected to efficiently combine different information sources in a quantifiable fashion to satisfy an information need, in this case for regulatory safety assessments. With increasing awareness of the limitations of each individual tool and the development of highly targeted tests and predictions, the need for combining pieces of evidence increases. The discussions that took place during this workshop, which brought together a group of experts coming from different related areas, illustrate the current state of the art of ITS, as well as promising developments and identifiable challenges. The case of skin sensitization was taken as an example to understand how possible ITS can be constructed, optimized and validated. This will require embracing and developing new concepts such as adverse outcome pathways (AOP), advanced statistical learning algorithms and machine learning, mechanistic validation and “Good ITS Practices”.
ID 15918
dauerhafte UFZ-Verlinkung
Rovida, C., Alépée, N., Api, A.M., Basketter, D.A., Bois, F.Y., Caloni, F., Corsini, E., Daneshian, M., Eskes, C., Ezendam, J., Fuchs, H., Hayden, P., Hegele-Hartung, C., Hoffmann, S., Hubesch, B., Jacobs, M.N., Jaworska, J., Kleensang, A., Kleinstreuer, N., Lalko, J., Landsiedel, R., Lebreux, F., Luechtefeld, T., Locatelli, M., Mehling, A., Natsch, A., Pitchford, J.W., Prater, D., Prieto, P., Schepky, A., Schüürmann, G., Smirnova, L., Toole, C., van Vliet, E., Weisensee, D., Hartung, T. (2015):
Integrated Testing Strategies (ITS) for safety assessment
ALTEX-Altern. Anim. Exp. 32 (1), 25 - 40