Details zur Publikation

Referenztyp Zeitschriften
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Titel (primär) Live cell imaging of the intracellular compartmentalization of the contaminate benzo[a]pyrene
Autor Ali, R.; Trump, S.; Lehmann, I.; Hanke, T.;
Journal / Serie Journal of Biophotonics
Erscheinungsjahr 2015
Department IMMU;
Band/Volume 8
Heft 5
Sprache englisch;
POF III (gesamt) F11; T42; T51;
Supplements https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fjbio.201300170&file=jbio201300170-sup-0001-author-biographies.pdf
Keywords Live cell imaging; Benzo[a]pyrene; 2-Photon; Confocal microscopy
UFZ Querschnittsthemen RU3;
Abstract This study investigates the cellular response of murine hepatoma cells to the polycyclic aromatic hydrocarbon benzo[a]pyrene (B[a]P) using two-photon and confocal laser scanning microscopy. The intracellular distribution of B[a]P and the B[a]P/AhR complex was visualized time- and concentration-dependent for up to 48 h of exposure. B[a]P was predominantly found in lipid droplets, endoplasmic reticulum and lysosomes, where B[a]P is collected and forms large aggregates. Changes in mitochondrial membrane potential and bleb formation due to high B[a]P concentrations were observed. The imaging data presented in this study provide new insights into the systemic cellular regulation following B[a]P exposure.
ID 14753
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=14753
Ali, R., Trump, S., Lehmann, I., Hanke, T. (2015):
Live cell imaging of the intracellular compartmentalization of the contaminate benzo[a]pyrene
J. Biophotonics 8 (5), 361 - 371