Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Carbamazepine and its metabolites in wastewater: Analytical pitfalls and occurrence in Germany and Portugal
Autor Bahlmann, A.; Brack, W.; Schneider, R.J.; Krauss, M.;
Journal / Serie Water Research
Erscheinungsjahr 2014
Department WANA;
Band/Volume 57
Sprache englisch;
POF III (gesamt) T42;
Keywords Carbamazepine; Hydroxycarbamazepine; Metabolite; Wastewater; Pharmaceutical; LC–MS/MS
UFZ Querschnittsthemen RU3;
Abstract The occurrence of carbamazepine (CBZ) and its metabolites in German and Portuguese wastewater was investigated. A total of 46 samples from influent and effluent wastewater were analyzed by liquid-chromatography (LC) tandem mass spectrometry. The five metabolites 10,11-dihydro-10,11-dihydroxy-CBZ (DiOH-CBZ), 10,11-dihydro-10-hydroxy-CBZ (10-OH-CBZ), 10,11-epoxy-10,11-dihydro-CBZ, 2-hydroxy-CBZ and 3-hydroxy-CBZ were very persistent with little to no removal during wastewater treatment. The highest concentrations were found for CBZ, DiOH-CBZ, and 10-OH-CBZ, with up to 5.0, 4.8 and 1.1 μg/L, respectively. Furthermore, the related pharmaceutical oxcarbazepine and the metabolites 9-hydroxymethyl-10-carbamoylacridan, 1-hydroxy-CBZ (1-OH-CBZ) and 4-hydroxy-CBZ (4-OH-CBZ) were detected. Explicit care was taken to achieve a good chromatographic separation of the numerous isomers that were difficult to distinguish by mass spectrometry alone. A phenylether stationary phase provided the best separation. In combination with high resolution mass spectrometry and hydrogen-deuterium exchange, this LC column enabled us to identify 1-OH-CBZ and 4-OH-CBZ in wastewater for the first time.
ID 14743
dauerhafte UFZ-Verlinkung http://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=14743
Bahlmann, A., Brack, W., Schneider, R.J., Krauss, M. (2014):
Carbamazepine and its metabolites in wastewater: Analytical pitfalls and occurrence in Germany and Portugal
Water Res. 57 , 104 - 114