Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
Titel (primär) Non-animal approaches for the predictive assessment of the aquatic toxicity of organic compounds
Autor Schüürmann, G.
Quelle Abstracts of Papers of the American Chemical Society
Erscheinungsjahr 2013
Department OEC
Band/Volume 246
Seite von 125-ENVR
Sprache englisch
UFZ Querschnittsthemen ru3
Abstract
Through the implementation of the European Directive REACH in 2007, alternative methods have gained importance as non-animal tools for the toxicological assessment of chemical substances. In this context, the 3R principle of reducing, refining and replacing animal testing has seen a paradigm shift, moving from 1:1 replacements to integrated testing strategies (ITS) that exploit the combined information from several non-animal methods (1:n replacement). In the presentation, non-test and test methods as major ITS components are outlined. The focus is on models to predict aquatic toxicity, employing quantitative read-across,1 structural alerts, and consensus modelling to compensate for individual method drawbacks. The discussion includes chemoassays to sense electrophilic reactivity,2 bioassays for deriving structural alerts,3 computational chemistry for predicting reactive toxicity4-5 as well as P450-catalysed biotransformation,6 and the issue of chemoavailability.7
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=14500
Schüürmann, G. (2013):
Non-animal approaches for the predictive assessment of the aquatic toxicity of organic compounds
Abstr. Paper Am. Chem. Soc. 246 , 125-ENVR