Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1089/ten.TEA.2012.0363
Titel (primär) The composition of engineered cartilage at the time of implantation determines the likelihood of regenerating tissue with a normal collagen architecture
Autor Nagel, T.; Kelly, D.J.
Quelle Tissue Engineering / Part A
Erscheinungsjahr 2013
Department ENVINF
Band/Volume 19
Heft 7-8
Seite von 824
Seite bis 833
Sprache englisch
UFZ Querschnittsthemen RU5;
Abstract The biomechanical functionality of articular cartilage is derived from both its biochemical composition and the
architecture of the collagen network. Failure to replicate this normal Benninghoff architecture in regenerating
articular cartilage may in turn predispose the tissue to failure. In this article, the influence of the maturity (or
functionality) of a tissue-engineered construct at the time of implantation into a tibial chondral defect on the
likelihood of recapitulating a normal Benninghoff architecture was investigated using a computational model
featuring a collagen remodeling algorithm. Such a normal tissue architecture was predicted to form in the intact
tibial plateau due to the interplay between the depth-dependent extracellular matrix properties, foremost
swelling pressures, and external mechanical loading. In the presence of even small empty defects in the articular
surface, the collagen architecture in the surrounding cartilage was predicted to deviate significantly from the
native state, indicating a possible predisposition for osteoarthritic changes. These negative alterations were
alleviated by the implantation of tissue-engineered cartilage, where a mature implant was predicted to result in
the formation of a more native-like collagen architecture than immature implants. The results of this study
highlight the importance of cartilage graft functionality to maintain and/or re-establish joint function and
suggest that engineering a tissue with a native depth-dependent composition may facilitate the establishment of
a normal Benninghoff collagen architecture after implantation into load-bearing defects.

dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=13317
Nagel, T., Kelly, D.J. (2013):
The composition of engineered cartilage at the time of implantation determines the likelihood of regenerating tissue with a normal collagen architecture
Tissue Eng. A 19 (7-8), 824 - 833 10.1089/ten.TEA.2012.0363