Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) A gene-dosage effect for interleukin-4 receptor α-chain expression has an impact on Th2-mediated allergic inflammation during bronchopulmonary mycosis
Autor Müller, U.; Stenzel, W.; Köhler, G.; Polte, T.; Blessing, M.; Mann, A.; Piehler, D.; Brombacher, F.; Alber, G.;
Journal / Serie Journal of Infectious Diseases
Erscheinungsjahr 2008
Department IMMU;
Band/Volume 198
Heft 11
Sprache englisch;
Abstract Interleukin (IL)-4 and IL-13 are key factors in the pathogenesis of bronchopulmonary mycosis induced in mice by infection with Cryptococcus neoformans. Both cytokines use the IL-4 receptor a-chain (IL-4Ra). In this study, we investigated the role played by IL-4Ra expression in susceptibility to pulmonary C. neoformans infection. IL-4Ra-/- mice were extremely resistant. To characterize the effect of IL-4Ra expression level on disease outcome, we generated IL-4Ra+/- first-generation (F1) mice. IL-4Ra+/- mice showed intermediate levels of IL-4Ra expression, in contrast to higher levels in wild-type mice and no expression in IL-4Ra-/- mice, indicating biallelic expression of the gene for IL-4Ra (Il4ra). Concomitant with intermediate IL-4Ra expression, F1 mice showed intermediate susceptibility associated with altered Th2/Th17 cytokine production, decreased immunoglobulin E levels, and reduced allergic inflammation. This indicates a gene-dosage effect of IL-4Ra expression on susceptibility to bronchopulmonary mycosis. These data provide the basis for novel therapies antagonizing IL-4Ra in Th2-related pulmonary infection and possibly also in asthma.
ID 1257
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=1257
Müller, U., Stenzel, W., Köhler, G., Polte, T., Blessing, M., Mann, A., Piehler, D., Brombacher, F., Alber, G. (2008):
A gene-dosage effect for interleukin-4 receptor α-chain expression has an impact on Th2-mediated allergic inflammation during bronchopulmonary mycosis
J. Infect. Dis. 198 (11), 1714 - 1721