Details zur Publikation
|DOI / URL||Link|
|Titel (primär)||Chemerin as a mediator between obesity and vascular inflammation in children|
|Autor||Landgraf, K.; Friebe, D.; Ullrich, T.; Kratzsch, J.; Dittrich, K.; Herberth, G.; Adams, V.; Kiess, W.; Erbs, S.; Körner, A.;|
|Journal / Serie||Journal of Clinical Endocrinology & Metabolism|
|Keywords||circulating adhesion molecules; human endothelial-cells; metabolic syndrome; coronary atherosclerosis; disease; adipogenesis; adipokine; receptor; adolescents; population|
Context: The chemoattractant protein chemerin has recently been shown to be expressed in adipose tissue.
Objective: We aimed to evaluate the association of chemerin with obesity and early-onset metabolic and vascular sequelae in children.
Design: We quantified chemerin serum levels in 69 lean and 105 obese children and assessed associations with metabolic and cardiovascular parameters. In addition, a potential direct effect of chemerin on the expression of endothelial adhesion molecules and cell viability was assessed in human coronary artery endothelial cells in vitro.
Results: Chemerin concentrations were significantly higher in obese compared to lean children and correlated with obesity-related parameters such as body mass index sd score, leptin, and skinfold thickness. Moreover, we identified significant associations with the measures of inflammation high-sensitivity C-reactive protein and white blood cell count, as well as with the markers of endothelial activation intercellular adhesion molecule-1 (ICAM-1) and E-selectin. Multiple regression analyses confirmed chemerin as the strongest predictor of ICAM-1 and E-selectin independent of body mass index sd score. Likewise, on the cellular level, chemerin induced ICAM-1 and E-selectin expression in endothelial cells in vitro, whereas VCAM-1 and eNOS expression and endothelial cell viability were unaffected.
Conclusion: Our results suggest an association of chemerin with obesity and inflammatory and endothelial activation markers and support a role for chemerin as a molecular link between increasing fat mass and an early atherogenic risk profile in obese children.
|Landgraf, K., Friebe, D., Ullrich, T., Kratzsch, J., Dittrich, K., Herberth, G., Adams, V., Kiess, W., Erbs, S., Körner, A. (2012):
Chemerin as a mediator between obesity and vascular inflammation in children
J. Clin. Endocrinol. Metab. 97 (4), E556 - E564