Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1016/j.envint.2012.01.010 |
| Titel (primär) | Identification and quantitative confirmation of dinitropyrenes and 3-nitrobenzanthrone as major mutagens in contaminated sediments |
| Autor | Lübcke-von Varel, U.; Bataineh, M.; Löffler, I.; Schulze, T.
; Flückiger-Isler, S.; Neca, J.; Machala, M.; Brack, W.; Lohrmann, S. |
| Quelle | Environment International |
| Erscheinungsjahr | 2012 |
| Department | WANA |
| Band/Volume | 44 |
| Heft | September 2012 |
| Seite von | 31 |
| Seite bis | 39 |
| Sprache | englisch |
| Keywords | Effect-directed analysis; Mutagen identification; Nitro-PAH; Ames fluctuation assay; LC–(APCI-)MS/MS |
| Abstract | Polar fractions of a sediment extract of the industrial area of Bitterfeld, Germany, have been subjected for effect-directed identification of mutagens using the Ames fluctuation assay with TA98. Mutagenicity could be well recovered in several secondary and tertiary fractions. Dinitropyrenes and 3-nitrobenzanthrone could be confirmed to contribute great shares of the observed mutagenicity. In addition, a multitude of polar polycyclic aromatic compounds has been tentatively identified in mutagenic fractions including nitro-PAHs, azaarenes, ketones, quinones, hydroxy-compounds, lactones and carboxylic acids although their contribution to mutagenicity could not be quantified due to a lack of standards. Diagnostic Salmonella strains YG1024 and YG1041 were applied to confirm the contribution of nitro-aromatic compounds. We suggest the inclusion of dinitropyrenes and 3-nitrobenzanthrone into sediment monitoring in order to minimize the mutagenic risk to aquatic organisms and to human health. |
| dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=12133 |
| Lübcke-von Varel, U., Bataineh, M., Löffler, I., Schulze, T., Flückiger-Isler, S., Neca, J., Machala, M., Brack, W., Lohrmann, S. (2012): Identification and quantitative confirmation of dinitropyrenes and 3-nitrobenzanthrone as major mutagens in contaminated sediments Environ. Int. 44 (September 2012), 31 - 39 10.1016/j.envint.2012.01.010 |
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