Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Identification and quantitative confirmation of dinitropyrenes and 3-nitrobenzanthrone as major mutagens in contaminated sediments
Autor Lübcke-von Varel, U.; Bataineh, M.; Löffler, I.; Schulze, T.; Flückiger-Isler, S.; Neca, J.; Machala, M.; Brack, W.; Lohrmann, S.;
Journal / Serie Environment International
Erscheinungsjahr 2012
Department WANA;
Band/Volume 44
Heft September 2012
Sprache englisch;
Keywords Effect-directed analysis; Mutagen identification; Nitro-PAH; Ames fluctuation assay; LC–(APCI-)MS/MS
Abstract

Polar fractions of a sediment extract of the industrial area of Bitterfeld, Germany, have been subjected for effect-directed identification of mutagens using the Ames fluctuation assay with TA98. Mutagenicity could be well recovered in several secondary and tertiary fractions. Dinitropyrenes and 3-nitrobenzanthrone could be confirmed to contribute great shares of the observed mutagenicity. In addition, a multitude of polar polycyclic aromatic compounds has been tentatively identified in mutagenic fractions including nitro-PAHs, azaarenes, ketones, quinones, hydroxy-compounds, lactones and carboxylic acids although their contribution to mutagenicity could not be quantified due to a lack of standards. Diagnostic Salmonella strains YG1024 and YG1041 were applied to confirm the contribution of nitro-aromatic compounds. We suggest the inclusion of dinitropyrenes and 3-nitrobenzanthrone into sediment monitoring in order to minimize the mutagenic risk to aquatic organisms and to human health.
ID 12133
dauerhafte UFZ-Verlinkung http://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=12133
Lübcke-von Varel, U., Bataineh, M., Löffler, I., Schulze, T., Flückiger-Isler, S., Neca, J., Machala, M., Brack, W., Lohrmann, S. (2012):
Identification and quantitative confirmation of dinitropyrenes and 3-nitrobenzanthrone as major mutagens in contaminated sediments
Environ. Int. 44 (September 2012), 31 - 39