Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Large deuterium isotope effects and their use: a historical review
Autor Krumbiegel, P.;
Journal / Serie Isotopes in Environmental and Health Studies
Erscheinungsjahr 2011
Department HDG;
Band/Volume 47
Heft 1
Sprache englisch;
Keywords hydrogen-2; isotope application; isotope effects; men; oils; pharmaceuticals; review; safety; stabilisation; technical use
Abstract

Isotope effects are differences in the properties of the isotopes of an element resulting in different reaction rates of a corresponding compound, in equilibrium constants and in the spectra. Shortly after the discovery of stable isotopes of hydrogen, oxygen, and carbon, Jacob Bigeleisen formulated a theory of isotope effects and calculated possible maximum values. Large isotope effects of 2H (deuterium) against 1H (protium) were seen to possibly influence interpretations of reaction mechanisms if corresponding labelling is used. Much work was invested to ensure the safety of deuterium use in men in spite of the large isotope effect. On the other hand, large deuterium isotope effects gave rise to several practical applications. Examples are the enhancement of the stability of some technical products against oxidative and against hydrolytic degradation (oils, pharmaceuticals) as well as alterations of the detoxification metabolism of pharmaceuticals in vivo.
ID 12101
dauerhafte UFZ-Verlinkung http://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=12101
Krumbiegel, P. (2011):
Large deuterium isotope effects and their use: a historical review
Isot. Environ. Health Stud. 47 (1), 1 - 17