Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1007/s12566-011-0026-1
Titel (primär) Aptamers for pharmaceuticals and their application in environmental analytics
Autor Strehlitz, B.; Reinemann, C.; Linkorn, S.; Stoltenburg, R.
Quelle Bioanalytical Reviews
Erscheinungsjahr 2012
Department UBZ
Band/Volume 4
Heft 1
Seite von 1
Seite bis 30
Sprache englisch
Keywords Aptamer; Small organic molecule; Pharmaceutical; Biosensor; Environmental analysis

Aptamers are single-stranded DNA or RNA oligonucleotides, which are able to bind with high affinity and specificity to their target. This property is used for a multitude of applications, for instance as molecular recognition elements in biosensors and other assays. Biosensor application of aptamers offers the possibility for fast and easy detection of environmental relevant substances. Pharmaceutical residues, deriving from human or animal medical treatment, are found in surface, ground, and drinking water. At least the whole range of frequently administered drugs can be detected in noticeable concentrations. Biosensors and assays based on aptamers as specific recognition elements are very convenient for this application because aptamer development is possible for toxic targets. Commonly used biological receptors for biosensors like enzymes or antibodies are mostly unavailable for the detection of pharmaceuticals. This review describes the research activities of aptamer and sensor developments for pharmaceutical detection, with focus on environmental applications.

dauerhafte UFZ-Verlinkung
Strehlitz, B., Reinemann, C., Linkorn, S., Stoltenburg, R. (2012):
Aptamers for pharmaceuticals and their application in environmental analytics
Bioanalytical Reviews 4 (1), 1 - 30 10.1007/s12566-011-0026-1