The central motivation for this book was the observation that megacities are places of inherent opportunity and risk. The book combines the empirical study of urban sectors in the Metropolitan Region of Santiago de Chile with theoretical considerations of risk and explores several common risk concepts. This final chapter provides a discussion and some conclusions to key questions. Firstly, it provides a systematic review of the extent to which different approaches to risk help to understand the Risk Habitat Megacity. Secondly, it considers what research methods and approaches are appropriate to understand the complex system that the Megacity is and provides orientation and action knowledge. Finally, and with special reference to the case of the Metropolitan Area of Santiago, it discusses what forms and strategies of governance constitute an adequate response to these challenges.