Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1111/j.1462-2920.2011.02516.x
Volltext Shareable Link
Titel (primär) The genome sequence of Desulfatibacillum alkenivorans AK-01: a blueprint for anaerobic alkane oxidation
Autor Callaghan, A.V.; Morris, B.E.L.; Pereira, I.A.C.; McInerney, M.J.; Austin, R.N.; Groves, J.T.; Kukor, J.J.; Suflita, J.M.; Young, L.Y.; Zylstra, G.J.; Wawrik, B.
Quelle Environmental Microbiology
Erscheinungsjahr 2012
Department ISOBIO
Band/Volume 14
Heft 1
Seite von 101
Seite bis 113
Sprache englisch
Abstract

Desulfatibacillum alkenivorans AK-01 serves as a model organism for anaerobic alkane biodegradation because of its distinctive biochemistry and metabolic versatility. The D. alkenivorans genome provides a blueprint for understanding the genetic systems involved in alkane metabolism including substrate activation, CoA ligation, carbon-skeleton rearrangement and decarboxylation. Genomic analysis suggested a route to regenerate the fumarate needed for alkane activation via methylmalonyl-CoA and predicted the capability for syntrophic alkane metabolism, which was experimentally verified. Pathways involved in the oxidation of alkanes, alcohols, organic acids and n-saturated fatty acids coupled to sulfate reduction and the ability to grow chemolithoautotrophically were predicted. A complement of genes for motility and oxygen detoxification suggests that D. alkenivorans may be physiologically adapted to a wide range of environmental conditions. The D. alkenivorans genome serves as a platform for further study of anaerobic, hydrocarbon-oxidizing microorganisms and their roles in bioremediation, energy recovery and global carbon cycling.

dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=11365
Callaghan, A.V., Morris, B.E.L., Pereira, I.A.C., McInerney, M.J., Austin, R.N., Groves, J.T., Kukor, J.J., Suflita, J.M., Young, L.Y., Zylstra, G.J., Wawrik, B. (2012):
The genome sequence of Desulfatibacillum alkenivorans AK-01: a blueprint for anaerobic alkane oxidation
Environ. Microbiol. 14 (1), 101 - 113 10.1111/j.1462-2920.2011.02516.x