Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Respiratory health in children, and indoor exposure to (1,3)-β-D-glucan, EPS mould components and endotoxin
Autor Tischer, C.; Gehring, U.; Chen, C.M.; Kerkhof, M.; Koppelman, G.; Sausenthaler, S.; Herbarth, O.; Schaaf, B.; Lehmann, I.; Krämer, U.; Berdel, D.; von Berg, A.; Bauer, C.P.; Koletzko, S.; Wichmann, H.-E.; Brunekreef, B.; Heinrich, J.;
Journal / Serie European Respiratory Journal
Erscheinungsjahr 2011
Department IMMU; STUDIEN;
Band/Volume 37
Heft 5
Sprache englisch;
Keywords Allergy; asthma; childhood; endotoxin; rhinitis
Abstract For a long time, exposure to mould and dampness derived microbial components was considered as risk factor for the development of respiratory diseases and symptoms. Some recent studies suggested that early childhood exposure to mould components such as (1,3)-beta-D-glucan and Extracellular Polysaccharides (EPS) may protect children from developing allergy. We investigated the association of the exposure to (1,3)-beta-D-glucan, EPS as well as endotoxin on asthma and allergies in 6 year old children. This investigation is the follow-up of an originally nested case-control study among three European birth cohorts. Children from two ongoing birth cohort studies performed in Germany (n=358) and one in The Netherlands (n=338) were selected. Levels of (1,3)-beta-D-glucan, EPS and endotoxin were measured in settled house dust sampled from children's mattress and living-room floor, when the children were on average 5 years old. At the age of 6 years, health outcome information was available for 678 children. In the two German subsets, domestic EPS and endotoxin exposure from children's mattresses was significantly negatively associated with physician-diagnosed asthma (OR (95% Confidence Interval per IQR increase), 0.60(0.39-0.92) and 0.55(0.31-0.97), respectively). In addition, EPS exposure was inversely related to physician-diagnosed allergic rhinitis (0.50(0.31-0.81)). For the Dutch population, no associations were observed between exposure to microbial agents and respiratory health outcomes. We found inverse associations between domestic exposure to EPS and endotoxin from children's mattresses and doctor-diagnosed asthma and rhinitis in German but not in Dutch school children. The reasons for the differences between countries are not clear.
ID 10954
dauerhafte UFZ-Verlinkung
Tischer, C., Gehring, U., Chen, C.M., Kerkhof, M., Koppelman, G., Sausenthaler, S., Herbarth, O., Schaaf, B., Lehmann, I., Krämer, U., Berdel, D., von Berg, A., Bauer, C.P., Koletzko, S., Wichmann, H.-E., Brunekreef, B., Heinrich, J. (2011):
Respiratory health in children, and indoor exposure to (1,3)-β-D-glucan, EPS mould components and endotoxin
Eur. Resp. J. 37 (5), 1050 - 1059