Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1080/15287394.2011.550555
Titel (primär) Effects-directed analysis of sediments from polluted marine sites in Norway
Autor Grung, M.; Naes, K.; Fogelberg, O.; Nilsen, A.J.; Brack, W.; Lübcke-von Varel, U.; Thomas, K.V.
Quelle Journal of Toxicology and Environmental Health, Part A
Erscheinungsjahr 2011
Department WANA
Band/Volume 74
Heft 7 & 9
Seite von 439
Seite bis 454
Sprache englisch
UFZ Querschnittsthemen RU2;
Abstract The environmental status of two polluted marine sites in Norway was investigated by a combination of target chemical analysis and effect-directed analysis (EDA). The two selected sites, the Grenland area and Oslo harbor, in addition to two reference sites, were classified according to the Norwegian environmental classification system based upon results of the target chemical analyses. The polluted sites were characterized by high levels of metals, polycyclic aromatic hydrocarbons (PAH), and polychlorinated biphenyls (PCB). High levels of organotin compounds were also detected in Oslo harbor. The aryl hydrocarbon receptor (AhR) agonist activity in extracts of sediments from marine sites close to Oslo, Oslo harbor, and Grenland were investigated using the CALUX (chemical-activated luciferase expression) assay, which showed elevated levels of activity. As expected from the history of dioxin release into the Grenland area, the results were highest in this area. The presence of estrogen receptor (ER) and androgen receptor (AR) antagonists was also detected in the sediment extracts. Following fractionation of the sediment extracts, EDA was used to tentatively identify the AhR agonists. The compounds responsible for AhR agonist activity in samples from Oslo harbor were isolated in fraction 13, and to a lesser extent in fractions 9-11. In Grenland, the main activity was found in the more polar fractions, namely fractions 14-18. The AhR agonists identified in Oslo harbor were mainly PAH, while in the Grenland area the compounds identified were mainly nitrogen/oxygen-containing polyaromatic compounds (N/O-PAC).
dauerhafte UFZ-Verlinkung
Grung, M., Naes, K., Fogelberg, O., Nilsen, A.J., Brack, W., Lübcke-von Varel, U., Thomas, K.V. (2011):
Effects-directed analysis of sediments from polluted marine sites in Norway
J. Toxicol. Env. Health Part A 74 (7 & 9), 439 - 454 10.1080/15287394.2011.550555