Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Syntheses with a chiral building block from the citric acid cycle: (2R,3S)-isocitric acid by fermentation of sunflower oil
Autor Heretsch, P.; Thoma, F.; Aurich, A.; Krautscheid, H.; Sicker, D.; Giannis, A.;
Journal / Serie Angewandte Chemie-International Edition
Erscheinungsjahr 2008
Department UBZ;
Band/Volume 47
Heft 10
Sprache englisch;
Keywords chiral pool; citric acid cycle; green chemistry; isocitric acid
Abstract

No longer just analytical: Previously, (2R,3S)-isocitric acid (1), a component of the citric acid cycle, had not been available on a preparative scale. A new route to this acid on a kilogram scale combines a biotechnological formation through fermentation from sunflower oil with a chemical separation process. In a variety of transformations into further chiral derivatives, 1 is established as a valuable new member of the chiral pool (see scheme).

ID 1028
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=1028
Heretsch, P., Thoma, F., Aurich, A., Krautscheid, H., Sicker, D., Giannis, A. (2008):
Syntheses with a chiral building block from the citric acid cycle: (2R,3S)-isocitric acid by fermentation of sunflower oil
Angew. Chem.-Int. Edit. 47 (10), 1958 - 1960