Paul Michaelis
Address:
Permoserstr. 15
04318 Leipzig
Germany
Building: 6.1
Room: 803
Phone: +49 341 6025 1823
Research Interests
In my current project, I aim to create a map of the zebrafish embryo transcriptome based on high resolution developmental data. On this map, toxicogenomic data can be explored to gain insight into the developmental processes disturbed in chemical-exposed zebrafish.
Beyond that I am interested in data integration and data driven approaches, utilising statistical modelling and data visualisation to contribute to a more comprehensive assessment of chemical risks in the environment.
Beyond that I am interested in data integration and data driven approaches, utilising statistical modelling and data visualisation to contribute to a more comprehensive assessment of chemical risks in the environment.
Curriculum Vitae
Since 2020
Scientist in the group of integrative toxicology (iTox), Helmholtz-Centre for Environmental Research - UFZ, Leipzig
2019 - 2020
Student Assistant in the group of integrative toxicology (iTox), Helmholtz-Centre for Environmental Research - UFZ, Leipzig
2019
Master thesis at the Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Young Investigators Group Bioinformatics & Transcriptomics
Title: "Analysis of time-dependent microarray datasets using Boolean networks"
2017 - 2019
M.Sc. in Bioinformatics at the University of Leipzig
2017
Bachelor thesis at BioReliance in Glasgow
Title: "Development of a real-time PCR assay for the detection of Vibrio cholerae and a ctxA deletion mutant"
2013 - 2017
B.Sc. in Biology at the University of Kaiserslautern
Publications
2025 (3)
- Michaelis, P., Klüver, N., Aulhorn, S., Bohring, H., Bumberger, J., Haase, K., Kuhnert, T., Küster, E., Krüger, J., Luckenbach, T., Massei, R., Nerlich, L., Petruschke, S., Schnicke, T., Schnurpel, A., Scholz, S., Schweiger, N., Sielaff, D., Busch, W. (2025):
Leveraging zebrafish embryo phenotypic observations to advance data-driven analyses in toxicology
Environ. Sci. Technol. 59 (9), 4304 - 4317 10.1021/acs.est.4c11757 - Nöth, J., Michaelis, P., Schüler, L., Scholz, S., Krüger, J., Haake, V., Busch, W. (2025):
Dynamics in zebrafish development define transcriptomic specificity after angiogenesis inhibitor exposure
Arch. Toxicol. 99 (4), 1561 - 1578 10.1007/s00204-024-03944-7 - Nöth, J., Michaelis, P., Schüler, L., Scholz, S., Krüger, J., Haake, V., Busch, W. (2025):
Correction to: Dynamics in zebrafish development define transcriptomic specificity after angiogenesis inhibitor exposure
Arch. Toxicol. 99 (4), 1579 10.1007/s00204-025-03998-1
2024 (2)
- Gutsfeld, S., Wehmas, L., Omoyeni, I.E., Schweiger, N., Leuthold, D., Michaelis, P., Howey, X.M., Gaballah, S., Herold, N., Vogs, C., Wood, C., Bertotto, L., Wu, G.-M., Klüver, N., Busch, W., Scholz, S., Schor, J., Tal, T. (2024):
Investigation of peroxisome proliferator-activated receptor genes as requirements for visual startle response hyperactivity in larval zebrafish exposed to structurally similar per- and polyfluoroalkyl substances (PFAS)
Environ. Health Perspect. 132 (7), art. 077007 10.1289/EHP13667 - Michaelis, P., Klüver, N., Busch, W. (2024):
Integrated Effect Database for Toxicological Observations (INTOB) [Data set]
Zenodo 10.5281/zenodo.11030299
2023 (2)
- Beckers, L.-M., Altenburger, R., Brack, W., Escher, B.I., Hackermüller, J., Hassold, E., Illing, G., Krauss, M., Krüger, J., Michaelis, P., Schüttler, A., Stevens, S., Busch, W. (2023):
A data-derived reference mixture representative of European wastewater treatment plant effluents to complement mixture assessment
Environ. Int. 179 , art. 108155 10.1016/j.envint.2023.108155 - Wilhelmi, P., Giri, V., Zickgraf, F.M., Haake, V., Henkes, S., Driemert, P., Michaelis, P., Busch, W., Scholz, S., Flick, B., Barenys, M., Birk, B., Kamp, H., Landsiedel, R., Funk-Weyer, D. (2023):
A metabolomics approach to reveal the mechanism of developmental toxicity in zebrafish embryos exposed to 6-propyl-2-thiouracil
Chem.-Biol. Interact. 382 , art. 110565 10.1016/j.cbi.2023.110565
2022 (1)
- Nöth, J., Michaelis, P., Busch, W., Scholz, S. (2022):
Analysis vascular disruptors in zebrafish embryos as an endpoint to predict developmental toxicity
Toxicol. Lett. 368 (Suppl.), S34 - S35 10.1016/j.toxlet.2022.07.111