Highly polar and persistent organic micropollutants (persistent and mobile organic chemicals, PMOCs) occurring in groundwater and surface water are of specific concern for drinking water production, since they break through natural and technical barriers. Additionally, PMOCs are very challenging to analyze. Therefore, knowledge about the occurrence of PMOCs in water cycles is scarce, which presents a threat for the protection of drinking water resources. PROMOTE focuses on PMOCs and aims at closing the significant knowledge gaps with respect to: (a) trace analytical methods for screening and quantitative determination of PMOCs in groundwater and surface water, (b) occurrence and levels of PMOCs in source water used for drinking water production, (c) environmental emissions, and (d) clean-up strategies in the drinking water production. Based on the expected results, PROMOTE strives to develop recommendations on how to protect our drinking water resources from PMOCs