.

Dr. Stephan Klähn

Tel.: +49-341-235 47 87
Mail: stephan.klaehn@ufz.de


Working Group:

Molecular Biology of Cyanobacteria


since 01/2018   Group leader at Helmholtz Centre for Environmental Research, Leipzig, Germany
Department of Solar Materials
09/2017 - 12/2017   Visiting Scientist at Oklahoma State University
Department of Microbiology and Molecular Genetics
Group of Prof. Robert L. Burnap
Stillwater (OK), USA
08/2017 - 09/2017   Visiting Scientist at Yale University
Department of Molecular, Cellular and Developmental Biology
Group of Prof. Ronald Breaker
New Haven (CT), USA
09/2014 - 12/2017   Researcher at Albert Ludwig University of Freiburg, Germany
Department of Genetics and Experimental Bioinformatics
08/2014   Visiting Scientist at Qingdao Institute of Bioenergy & Bioprocess Technology
Group of Prof. Xuefeng Lu
Qingdao, China
11/2010 - 08/2014   PostDoc at Albert Ludwig University of Freiburg, Germany
Department of Genetics and Experimental Bioinformatics
Group of Prof. Wolfgang R. Hess
10/2010   PhD in Molecular Biology, University of Rostock, Germany
06/2008   Visiting Scientist at Max-Planck Institute of Molecular Plant Physiology
Group of Dr. Dirk Hincha
Potsdam-Golm, Germany
10/2006 - 09/2010   PhD student at University of Rostock, Germany
Department of Plant Physiology
Group of Prof. Martin Hagemann
10/2001 - 09/2006   Studies of biology at University of Rostock, Germany
with specialization in plant physiology, molecular biology, biochemistry and bioorganic chemistry

2018 (1)

  • Hagemann M., Gärtner K., Scharnagl M., Bolay P., Lott S., Fuss J., Huettel B., Reinhardt R., Klähn S., Hess W.R. (2018)
    Identification of the DNA methyltransferases establishing the methylome of the cyanobacterium Synechocystis sp. PCC 6803.
    DNA Research, in press


2017 (3)

  • Kuchmina E., Klähn S., Jakob A., Bigott W., Enke H., Dühring U., Wilde A. (2017)
    Ethylene production in Synechocystis sp. PCC 6803 promotes phototactic movement.
    Microbiology, 163 (12), 1937-1945.

  • Kirsch F., Pade N., Klähn S., Hess W.R., Hagemann M. (2017)

    The glucosylglycerol-degrading enzyme GghA is involved in acclimation to fluctuating salinities by the cyanobacterium Synechocystis sp. strain PCC 6803.
    Microbiology
    , 163 (9), 1319-1328.


  • Georg J., Kostova G., Vuorijoki L., Schön V., Kadowaki T., Huokko T., Baumgartner D., Müller M., Klähn S., Allahverdiyeva Y., Hihara Y., Futschik M.E., Aro E.M., Hess W.R. (2017)
    Acclimation of oxygenic photosynthesis to iron starvation is controlled by the sRNA IsaR1.
    Current Biology
    27 (10):1425-1436.e7.


2016 (3)

  • Baumgartner D., Kopf M., Klähn S., Steglich C., Hess WR. (2016)
    Small proteins in cyanobacteria provide a paradigm for the functional analysis of the bacterial micro-proteome.
    BMC Microbiology 16:285


  • Orf I., Schwarz D., Kaplan A., Kopka J., Hess W.R., Hagemann M., Klähn S.* (2016)
    CyAbrB2 contributes to the transcriptional regulation of Low CO2 acclimation in Synechocystis sp. PCC 6803.
    Plant and Cell Physiology 57(10): 2232–2243.
    *corresponding author

  • de Porcellinis A.J.*, Klähn S.*, Rosgaard L., Kirsch R., Gutekunst K., Georg J., Hess W.R., Sakuragi Y. (2016)
    The non-coding RNA Ncr0700/PmgR1 is required for photomixotrophic growth and the regulation of glycogen accumulation in the cyanobacterium Synechocystis sp. PCC 6803.
    Plant and Cell Physiology 57(10): 2091–2103.
    *shared first authors

2015 (4)

  • Klähn S., Schaal C., Georg J., Baumgartner D., Knippen G., Hagemann M., Muro-Pastor A.M., Hess W.R. (2015)
    The sRNA NsiR4 is involved in nitrogen assimilation control in cyanobacteria by targeting glutamine synthetase inactivating factor IF7.
    Proceedings of the National Academy of Sciences of the United States of America 112 (45): E6243 - E6252.

  • Orf I., Klähn S., Schwarz D., Frank M., Hess W.R., Hagemann M., Kopka J. (2015)
    Integrated analysis of engineered carbon limitation in a quadruple CO2/HCO3- uptake mutant of Synechocystis sp. PCC 6803.
    Plant Physiology 169: 1787 - 1806

  • Kopf M.*, Klähn S.*, Scholz I., Hess W.R., Voß B. (2015)
    Variations in the non-coding transcriptome as a driver of inter-strain divergence and physiological adaptation in bacteria.
    Scientific Reports 5: 9560.
    *shared first authors

  • Klähn S., Orf I., Schwarz D., Matthiessen J.K.F., Kopka J., Hess W.R., Hagemann M. (2015)
    Integrated transcriptomic and metabolomic characterization of the low-carbon response using an ndhR mutant of Synechocystis sp. PCC 6803.
    Plant Physiology 169: 1540 - 1556

2014 (5)

  • Georg J., Dienst D., Schürgers N., Wallner T., Kopp D., Stazic D., Kuchmina E., Klähn S., Lokstein H., Hess W.R., Wilde A. (2014)
    The small regulatory RNA PsrR1 controls photosynthetic functions in cyanobacteria.
    The Plant Cell 26 (9): 3661 - 3679.

  • Kopf M., Klähn S., Voß B., Stüber K., Huettel B., Reinhardt R., Hess W.R. (2014)
    Finished genome sequence of the unicellular cyanobacterium Synechocystis sp. strain PCC 6714.
    Genome Announcements 2 (4): e00757-14.

  • Klähn S., Baumgartner D., Pfreundt U., Voigt K., Schön V., Steglich C., Hess W.R. (2014)
    Alkane biosynthesis genes in cyanobacteria and their transcriptional organization.
    Frontiers in Bioengineering and Biotechnology 2: 24.

  • Kopf M.*, Klähn S.*, Scholz I., Matthiessen J.K.F., Hess W.R., Voß B. (2014)
    Comparative analysis of the primary transcriptome of Synechocystis sp. PCC 6803.
    DNA Research 21 (5): 527 - 539.
    *shared first authors

  • Kopf M.*, Klähn S.*, Pade N., Weingärtner C., Hagemann M., Voß B., Hess W.R. (2014)
    Comparative genome analysis of the closely related Synechocystis strains PCC 6714 and PCC 6803.
    DNA Research 21 (3):255 - 266.
    *shared first authors, Editor’s choice (Highlighting article in Volume 21, Issue 3)


2013 (1)

  • Sievers N., Muders K., Henneberg M., Klähn S., Effmert M., Junghans H., Hagemann M. (2013)
    Establishing glucosylglycerol synthesis in potato (Solanum tuberosum L. cv. Albatros) by expression of the ggpPS gene from Azotobacter vinelandii.
    Journal of Plant Science and Molecular Breeding 2: 1.

2012 (2)

  • Eisenhut M., Georg J., Klähn S., Sakurai I., Mustila H., Zhang P., Hess W.R., Aro E.M. (2012)
    The antisense RNA As1_flv4 in the cyanobacterium Synechocystis sp. PCC 6803 prevents premature expression of the flv4-2 operon upon shift in inorganic carbon supply.
    Journal of Biological Chemistry 287 (40): 33153 -33162.

  • Pade N., Compaoré J., Klähn S., Stal L.J., Hagemann M. (2012)
    The marine cyanobacterium Crocosphaera watsonii WH8501 synthesizes the compatible solute trehalose by a laterally acquired OtsAB fusion protein.
    Environmental Microbiology 14: 1261 -1271.2009 (2)

2011 (1)

  • Klähn S. and Hagemann M. (2011)
    Compatible solute biosynthesis in cyanobacteria.
    Environmental Microbiology 13: 551 - 562.


2010 (2)

  • Klähn S., Höhne A., Simon E., Hagemann M. (2010)
    The gene ssl3076 encodes a protein mediating the salt -induced expression of ggpS for the biosynthesis of the compatible solute glucosylglycerol in Synechocystis sp. strain PCC 6803.
    Journal of Bacteriology 192: 4403 -4412.

  • Klähn S., Steglich C., Hess W.R., Hagemann M. (2010)
    Glucosylglycerate: a secondary compatible solute common to marine cyanobacteria from nitrogen-poor environments.
    Environmental Microbiology 12: 83 – 94.


2009 (1)

  • Klähn S., Marquardt D.M., Rollwitz I., Hagemann M. (2009)
    Expression of the ggpPS gene for glucosylglycerol biosynthesis from Azotobacter vinelandii improves the salt tolerance of Arabidopsis thaliana.
    Journal of Experimental Botany 60: 1679 - 1689


2008 (1)

  • Hagemann M., Ribbeck-Busch K., Klähn S., Hasse D., Steinbruch R., Berg G. (2008)
    The plant-associated bacterium Stenotrophomonas rhizophila expresses a new enzyme for the synthesis of the compatible solute glucosylglycerol.
    Journal of Bacteriology 190: 5898 - 5906.