Chapter 13
Design of test batteries and interpretation of bioassay results
What are multiplexed high-throughput assays and what are their pros and cons?
What is the so-called “iceberg (mixture) modelling“, and when can it be used?
In vitro bioassays can be divided in two categories (Category 1 and Category 2 bioassays). What is the difference between these two categories and what criteria can be used to determine whether a bioassay is category 1 or 2? Give examples for each category.
What are EBTs (Effect-based trigger values) and why are they important for the interpretation of bioassay data?
Explain the proposed action that is advised if the measured effect in water samples exceeds the proposed EBT. What are the necessary steps in screening, targeted analysis and exploration?