Fish and frog embryos

Fish and amphibian embryos as alternative models in toxicology and teratology

29.- 30. November 2018, Aulnay-sous-Bois/Paris, France

5th international symposium and workshop

with optional workshops on data analysis, methods and concepts on the 28th of November


We are most happy to announce the 2nd special issue on "Zebrafish: A Model for Toxicological Research" in the International Journal of Molecular Sciences. Please find detailed information on this together with application possibilities under "Special Issue" in the left hand menu.

Invited speakers and tentative titles

David Reif (North Carolina State University) - Leveraging high-throughput screening data to find evidence for susceptibility differences in genetically diverse zebrafish

Wibke Busch (UFZ) - ZFE-Toxicogenomics - from snapshot observations towards dynamic response modelling 

Erica Davis (Duke University) -  Modeling pediatric genetic disease in the developing zebrafish

Steven C. Cassar (Abbvie) - Evaluating the zebrafish developmental assay for predicting embryotoxic chemical plasma levels in mammals

Luigi Margiotta-Casaluci (Brunel University) - Analysis of inflammation-mediated mechanisms of toxicity of drugs in zebrafish early life stage

Pim Leonards (Vrije Universiteit Amsterdam) - Metabolome analysis in zebrafish embryos

Matthew Winter (Exeter University) - Brain pharmacological profiling in zebrafish embryos               


Fish and amphibian embryo models are highly popular in the area of toxicology, both in research, industry and potential regulatory application. These models exhibit a number of advantages which make them superior and/or complementary to others. In compliance with international animal welfare regulations, the fish and amphibian embryo models provide an ethically acceptable small scale analysis system with the complexity of a complete organism. A suite of available advanced methodologies allows various types of experimental approaches ranging from phenotypic observations, functional assays to “omics” analysis. The ultimate goal of the symposium is to promote the development of the fish and frog embryo models as potential alternatives to animal testing.
Four exciting symposia were held between 2010 and 2016 with a strong focus on the zebrafish model. The symposium aims to bring together scientists using fish and frog embryo models, exchange knowledge, ideas and latest developments in the field of toxicology and teratology. Invited lectures will focus on specific topics. Breakout sessions will allow to identify major advantages, limitations, new fields and future research needs of the fish/amphibian embryo model and to establish collaborations.

Three breakout sessions are at present planned (session 1 will kindly be supported and organised by Joop de Knecht and Leo van der Ven, RIVM)

1. Combining toxicokinetics, biotransformation  and AOP development in zebrafish embryos for development of predictive assays

2. Testing for neuroactivity/-toxicity

3. Prediction of developmental toxicity/integrating testing strategies

There might be slight changes in the topics of the breakout sessions depending on the interest of the participants and their contributions.

Contributions welcome

Contributions from participants, both poster presentations and platform presentations are welcome. These presentations could cover one of the following topics: human toxicology screening, teratogenicity, nanotoxicology, immunotoxicity, regulatory toxicology, endocrine effects, neurotoxicity, toxicogenomics (‘omics‘), high throughput technologies, functional genomics, ethics/animal welfare and ecotoxicology (acute and chronic toxicity, bioconcentration, effluent testing). Presentations can be made in the general platform or in breakout sessions with specific topics.

Program, registration, conference venue

For further questions please contact Stefan Scholz, Helmholtz Centre for Environmental Research, Leipzig, Germany (+49 341 235 1080)

Mailing list

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Stefan Scholz

Marc Léonard

Scientific organising committee

Stefan Scholz UFZ
Mark Léonard L'Oréal
Noémie de Crozé L'Oréal
Jessica Legradi IVM (VU Amsterdam)
Aldert Piersma RIVM
Peter de Witte Univ. Leuven
Stephanie Padilla US EPA
Juliette Legler IRAS (Utrecht Univ.)

An activity of the UFZ research programme: