Fish and frog embryos

Fish and amphibian embryos as alternative models in toxicology and teratology

1.- 2. December 2016, Aulnay-sous-Bois/Paris, France

                    An international symposium & workshop

Invited speakers

Peter Aleström (Norwegian University of Life Sciences) - Zebrafish embryo epigenetics

Daniëlle Copmans (KU Leuven) – Phenotype clustering of neuroactive compounds using the photomotor response analysis            

Thorsten Meinl ( AG) -  Data Analysis with the KNIME Analytics Platform       

Stephanie Padilla (US-EPA) - Screening of the ToxCast Phase I and II Chemicals Using Zebrafish Embryos

Christian Pylatiuk (Karlsruhe Institute of Technology) - Automated feature detection and screening in zebrafish embryos

Thorsten Reemtsma (Helmholtz Centre for Environmental Research) - Uptake and biotransformationn of chemicals in zebrafish embryos

David C. Volz (University of California) - High-Content Screening of Chemical Toxicity in Zebrafish Embryos                

Mehmet Fatih Yanik (ETH Zurich) - Hyper-dimensional screening of zebrafish embryos at cellular resolution with VAST


Fish and amphibian embryo models are highly popular in the area of toxicology, both in research, industry and potential regulatory application. These models exhibit a number of advantages which make them superior and/or complementary to others. In compliance with international animal welfare regulations, the fish and amphibian embryo models provide an ethically acceptable small scale analysis system with the complexity of a complete organism. A suite of available advanced methodologies allows various types of experimental approaches ranging from phenotypic observations, functional assays to “omics” analysis. The ultimate goal of the symposium is to promote the development of the fish and frog embryo models as potential alternatives to animal testing.
Three exciting symposia were held between 2010 and 2014 with a strong focus on the zebrafish model. While the zebrafish will remain one of the most important model our symposium is open to other fish and amphibian species with similar features. The symposium aims to bring together scientists using fish and frog embryo models, exchange knowledge, ideas and latest developments in the field of toxicology and teratology. Invited lectures will focus on specific topics. Breakout sessions will allow to identify major advantages, limitations, new fields and future research needs of the fish/amphibian embryo model and to establish collaborations.

The focus in 2016 will be on but not limited to high-content/image analysis, behavourial assays and AOPs.

Contributions welcome

Contributions from participants, both poster presentations and a limited number of short platform presentations are welcome. These presentations could cover one of the following topics: human toxicology screening, teratogenicity, nanotoxicology, immunotoxicity, regulatory toxicology, endocrine effects, neurotoxicity, toxicogenomics (‘omics‘), high throughput technologies, functional genomics, ethics/animal welfare and ecotoxicology (acute and chronic toxicity, bioconcentration, effluent testing). Please note that you also have the possibility to present data and results in the breakout sessions!

Program, registration, conference venue

Symposium poster

For further questions please contact Stefan Scholz, Helmholtz Centre for Environmental Research, Leipzig, Germany (+49 341 235 1080)

Mailing list

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Stefan Scholz

Marc Léonard

Scientific organising committee

Stefan Scholz UFZ
Mark Léonard L'Oréal
Noémie de Crozé L'Oréal
Jessica Legradi IVM (VU Amsterdam)
Aldert Piersma RIVM
Peter de Witte Univ. Leuven
Stephanie Padilla US EPA
Juliette Legler IRAS (Utrecht Univ.)

An activity of the UFZ research programme: