Dr. Christian Eberlein

Helmholtz Centre for Environmental Research - UFZ
Department of Environmental Biotechnology
Permoserstraße 15
D-04318 Leipzig, Germany

Tel. +49 341 235 1765

Christian Eberlein

Research

My research is embedded in the research project NO-STRESS, which is funded by the Federal Ministry of Education and Research of Germany (Bundesministerium für Bildung und Forschung, BMBF). Together with the Helmholtz Centre Jülich and the University of Düsseldorf we want to provide robust bacterial cell factories with high tolerance to key chemical stressors. Such cell factories can be used for the biotechnological production of fine chemicals used as pharmaceuticals or chemical building blocks.


I was part of the EU-Project P4SB (From Plastic waste to Plastic value using Pseudomonas putida Synthetic Biology; http://www.p4sb.eu/; 2015-2019) which aimed to transform conventional plastics gained from fossil fuels into bioplastics; employing Pseudomonas putida for the degradation of oligomeric resins.


Member of MiKat - Centre for Biocatalysis (http://www.mikat.info/)

Curriculum Vitae

2009

Diploma in Biology; University of Leipzig

2009 - 2013

PhD in Biochemistry/Microbiology, University of Leipzig and University of Freiburg, within EU-Project MAGICPAH

http://www.magicpah.org

2013 - 2015

Postdoc researcher at the University Hospital Carl Gustav Carus Dresden

Since 05/2015

Postdoc researcher, Helmholtz Centre for Environmental Research - UFZ, Department of Environmental Biotechnology

Publications

Eberlein C, Baumgarten T, Starke S, Heipieper HJ (2018) Immediate response mechanisms of Gram-negative solvent-tolerant bacteria to cope with environmental stress: cis-trans isomerization of unsaturated fatty acids and outer membrane vesicle secretion. Applied Microbiology and Biotechnology 102(6):2583-2593. doi:10.1007/s00253-018-8832-9

Eberlein C, Estelmann S, Seifert J, von Bergen M, Muller M, Meckenstock RU, Boll M (2013) Identification and characterization of 2-naphthoyl-coenzyme A reductase, the prototype of a novel class of dearomatizing reductases. Mol Microbiol 88(5):1032-1039. doi:10.1111/mmi.12238

Eberlein C, Johannes J, Mouttaki H, Sadeghi M, Golding BT, Boll M, Meckenstock RU (2013) ATP-dependent/-independent enzymatic ring reductions involved in the anaerobic catabolism of naphthalene. Environ Microbiol 15(6):1832-1841. doi:10.1111/1462-2920.12076

Eberlein C, Starke S, Doncel AE, Scarabotti F, Heipieper HJ (2019) Quantification of outer membrane vesicles: a potential tool to compare response in Pseudomonas putida KT2440 to stress caused by alkanols. Appl Microbiol Biotechnol 103(10):4193-4201. doi:10.1007/s00253-019-09812-0

Espinosa MJC, Blanco AC, Schmidgall T, Atanasoff-Kardjalieff AK, Kappelmeyer U, Tischler D, Pieper DH, Heipieper HJ, Eberlein C (2020) Toward Biorecycling: Isolation of a Soil Bacterium That Grows on a Polyurethane Oligomer and Monomer. Front Microbiol 11:404 doi:10.3389/fmicb.2020.00404

Georgi JA, Taube F, Kramer M, Herold S, Rollig C, Eberlein C, Stasik S, Kramer A, Berdel WE, Serve H, Platzbecker U, Bornhauser M, Ehninger G, Schetelig J, Thiede C, SAL SL (2016) Mutational profiling of AML patients with CEBPA-mutations reveals differences between biallelic and monoallelic TAD and bZIP mutant subgroups. Oncology Research and Treatment 39:45-45.

Georgi JA, Taube F, Kramer M, Herold S, Schaefer-Eckart K, Schmitz N, Eberlein C, Stasik S, Aulitzky WE, Kraemer A, Roesler W, Haenel M, Einsele H, Baldus CD, Middeke JM, Platzbecker U, Roellig C, Serve H, Berdel WE, Ehninger G, Bornhaeuser M, Schetelig J, Thiede C (2016) Differences Between CEBPA bZIP and TAD Mutations and Their Effect on Outcome-an Analysis in 4578 Patients with Acute Myeloid Leukemia. Blood 128(22):283

Heipieper HJ, Pepi M, Baumgarten T, Eberlein C (2017) Surface properties and cellular energetics of bacteria in response to the presence of hydrocarbons. In: Krell T. (Ed.) Handbook of Hydrocarbon and Lipid Microbiology. Cellular Ecophysiology of Microbe. Springer, Berlin, Heidelberg. Chapter 26. pp. 397-408

Juarez JF, Liu H, Zamarro MT, McMahon S, Liu H, Naismith JH, Eberlein C, Boll M, Carmona M, Diaz E (2015) Unraveling the specific regulation of the central pathway for anaerobic degradation of 3-methylbenzoate. J Biol Chem 290(19):12165-1283. doi:10.1074/jbc.M115.637074

Juarez JF, Zamarro MT, Eberlein C, Boll M, Carmona M, Diaz E (2013) Characterization of the mbd cluster encoding the anaerobic 3-methylbenzoyl-CoA central pathway. Environ Microbiol 15(1):148-166. doi:10.1111/j.1462-2920.2012.02818.x

Lahme S, Eberlein C, Jarling R, Kube M, Boll M, Wilkes H, Reinhardt R, Rabus R (2012) Anaerobic degradation of 4-methylbenzoate via a specific 4-methylbenzoyl-CoA pathway. Environ Microbiol 14(5):1118-1132. doi:10.1111/j.1462-2920.2011.02693.x

Löffler C, Eberlein C, Mausezahl I, Kappelmeyer U, Heipieper HJ (2010) Physiological evidence for the presence of a cis-trans isomerase of unsaturated fatty acids in Methylococcus capsulatus Bath to adapt to the presence of toxic organic compounds. FEMS Microbiol Lett 308(1):68-75. doi:10.1111/j.1574-6968.2010.01993.x

Trautwein K, Grundmann O, Wohlbrand L, Eberlein C, Boll M, Rabus R (2012) Benzoate mediates repression of C(4)-dicarboxylate utilization in "Aromatoleum aromaticum" EbN1. J Bacteriol 194(2):518-528. doi:10.1128/JB.05072-11

Wierckx N, Narancic T, Eberlein C, Wei R, Drzyzga O, Magnin A, Ballerstedt H, Kenny S, Pollet E, Avérous L, O’Connor KE, Zimmermann W, Heipieper HJ, Prieto A, Jiménez J, Blank LM (2019) Plastic Biodegradation: Challenges and Opportunities. In: Steffan R (ed) Consequences of Microbial Interaction with Hydrocarbons, Oils and Lipids: Biodegradation and Bioremediation. Handbook of Hydrocarbon and Lipid Microbiology. Springer, in press. DOI: 10.1007/978-3-319-44535-9_23-1