Dr. Christian Eberlein

Tel. +49 341 235 1765

Christian Eberlein

Research

My research is embedded in the research project NO-STRESS, which is funded by the Federal Ministry of Education and Research of Germany (Bundesministerium für Bildung und Forschung, BMBF). Together with the Helmholtz Centre Jülich and the University of Düsseldorf we want to provide robust bacterial cell factories with high tolerance to key chemical stressors. Such cell factories can be used for the biotechnological production of fine chemicals used as pharmaceuticals or chemical building blocks.


I was part of the EU-Project P4SB (From Plastic waste to Plastic value using Pseudomonas putida Synthetic Biology; http://www.p4sb.eu/; 2015-2019) which aimed to transform conventional plastics gained from fossil fuels into bioplastics; employing Pseudomonas putida for the degradation of oligomeric resins.


Member of MiKat - Centre for Biocatalysis (http://www.mikat.info/)

Curriculum Vitae

2009

Diploma in Biology; University of Leipzig

2009 - 2013

PhD in Biochemistry/Microbiology, University of Leipzig and University of Freiburg, within EU-Project MAGICPAH

http://www.magicpah.org

2013 - 2015

Postdoc researcher at the University Hospital Carl Gustav Carus Dresden

Since 05/2015

Postdoc researcher, Helmholtz Centre for Environmental Research - UFZ, Department of Environmental Biotechnology

Publications

2020 (5)

2019 (2)

2018 (2)

2010 (1)

Other Publications

Georgi JA, Taube F, Kramer M, Herold S, Rollig C, Eberlein C, Stasik S, Kramer A, Berdel WE, Serve H, Platzbecker U, Bornhauser M, Ehninger G, Schetelig J, Thiede C, SAL SL (2016) Mutational profiling of AML patients with CEBPA-mutations reveals differences between biallelic and monoallelic TAD and bZIP mutant subgroups. Oncology Research and Treatment 39:45-45.

Georgi JA, Taube F, Kramer M, Herold S, Schaefer-Eckart K, Schmitz N, Eberlein C, Stasik S, Aulitzky WE, Kraemer A, Roesler W, Haenel M, Einsele H, Baldus CD, Middeke JM, Platzbecker U, Roellig C, Serve H, Berdel WE, Ehninger G, Bornhaeuser M, Schetelig J, Thiede C (2016) Differences Between CEBPA bZIP and TAD Mutations and Their Effect on Outcome-an Analysis in 4578 Patients with Acute Myeloid Leukemia. Blood 128(22):283

Juarez JF, Liu H, Zamarro MT, McMahon S, Liu H, Naismith JH, Eberlein C, Boll M, Carmona M, Diaz E (2015) Unraveling the specific regulation of the central pathway for anaerobic degradation of 3-methylbenzoate. J Biol Chem 290(19):12165-1283. doi:10.1074/jbc.M115.637074

Juarez JF, Zamarro MT, Eberlein C, Boll M, Carmona M, Diaz E (2013) Characterization of the mbd cluster encoding the anaerobic 3-methylbenzoyl-CoA central pathway. Environ Microbiol 15(1):148-166. doi:10.1111/j.1462-2920.2012.02818.x

Eberlein C, Estelmann S, Seifert J, von Bergen M, Muller M, Meckenstock RU, Boll M (2013) Identification and characterization of 2-naphthoyl-coenzyme A reductase, the prototype of a novel class of dearomatizing reductases. Mol Microbiol 88(5):1032-1039. doi:10.1111/mmi.12238

Eberlein C, Johannes J, Mouttaki H, Sadeghi M, Golding BT, Boll M, Meckenstock RU (2013) ATP-dependent/-independent enzymatic ring reductions involved in the anaerobic catabolism of naphthalene. Environ Microbiol 15(6):1832-1841. doi:10.1111/1462-2920.12076

Lahme S, Eberlein C, Jarling R, Kube M, Boll M, Wilkes H, Reinhardt R, Rabus R (2012) Anaerobic degradation of 4-methylbenzoate via a specific 4-methylbenzoyl-CoA pathway. Environ Microbiol 14(5):1118-1132. doi:10.1111/j.1462-2920.2011.02693.x

Trautwein K, Grundmann O, Wohlbrand L, Eberlein C, Boll M, Rabus R (2012) Benzoate mediates repression of C(4)-dicarboxylate utilization in "Aromatoleum aromaticum" EbN1. J Bacteriol 194(2):518-528. doi:10.1128/JB.05072-11