Dr. Janina Tomm

Kontakt/Adresse

Dr. Janina Tomm
Wissenschaftliche Mitarbeiterin,

Department Proteomik
Helmholtz-Zentrum
für Umweltforschung - UFZ
Permoserstr. 15
04318 Leipzig, Germany

Tel: 0341 235 1819
Fax: 0341 235 1787
janina.tomm @ ufz.de

Persönliche Bild

Forschungsinteresse/ Schwerpunkt

Zelluläre RNAs, die nicht als Messenger-RNA (mRNA), Transfer-RNA (t-RNA) oder ribosomale RNA (r-RNA) fungieren, setzen sich aus einer Vielzahl unterschiedlicher RNA-Klassen zusammen, die als nicht-protein-kodierende RNAs (ncRNAs) zusammengefasst werden. Die Anzahl der identifizierten ncRNAs hat in den letzten Jahren stark zugenommen, genauso wie die Erkenntnisse über ihre Funktionsweisen. Dabei wurde gefunden, dass viele ncRNAs eine regulatorische Funktion bei der Steuerung der Proteinexpression besitzen. Solche regulatorischen RNAs wurden sowohl in Prokaryoten als auch in Eukaryoten gefunden. Ergebnisse des letzten Jahrzehnts weisen daraufhin, dass RNA-abhängige Regulationsmechanismen insbesondere bei der Feinregulation der Proteinexpression beteiligt sind. Eine derartige Feinregulation ist bei der Differenzierung von Immunzellen von besonderer Bedeutetung.
Von daher fokussieren wir auf die Wirkung von ncRNAs auf die Proteinexpression in Immunzellen in Verbindung mit dem Einfluss von Umweltschadstoffen.

Methoden

- Kultivierung von eukaryotischen Zellen

- Identifizierung und von ncRNAs, sowie derern Klonierung und Überexpression in eukaryotischen Zellen

- Massenspektrometrische Identifizierung von differentiell exprimierten Proteinen

- Durchführung von SILAC (stable isotope labeling with amino acids in cell culture)- Experimenten zur Untersuchung der Regulation der Genexpression, von Zellsignaling und Protein-Protein-Interaktion

Lebenslauf

seit 2009

Helmholtzzentrum für Umweltforschung, Department Proteomics

2004-2008

MPI für molekulare Biomedizin, Münster

Doktorabeit/ Postdoc in der Abteilung "Vaskuläre Zellbiologie"
Leitung: Prof. Dr. Dietmar Vestweber
Thema der Arbeit: „ Interaktion von VE-Cadherin und VE-PTP“

2002-2003

University of Auckland, School of Biological Sciences, Department of Structural Biology

Principal Investigator: Assoc. Prof. Ph.D. Peter Metcalf
Reseach project I: “Influenza evolution studies using virus preserved in Antarctic ice” (main project)
Research project II: “Over-expression, purification and crystallisation of a variant E.coli protein of the thioredoxin-cascade” (two month insight)

2000-2001

University of Liverpool, Großbritanien

1998-2004

Universität Hamburg, Fachbereich Biologie

Diplomarbeit in der Abteilung „Angewandte Molekularbiologie der Pflanzen I“
Leitung: Prof. Dr. Udo Wienand
Thema der Arbeit: „Klonierung und Expression von Phytosulfokin-Precursor homologen Genen (ZmPSK) aus Zea mays (L.)“

Weitere Qualifikationen

- Teilnahme am Kurs für Versuchstierkunde

- Fernstudium der Betriebswirtschaftslehre an der ILS, Hamburg

- Teilnahme an Seminaren der Patentoffensive Westfalen Ruhr

 
 

Publikationen / Publications


2013

Pyruvate kinase and phosphopyruvate hydratase as novel IgE reactive proteins in prawn. Tomm JM, Krause C, Simon JC, Treudler R, von Bergen M, Averbeck M. Investigational Allergology and Clinical Immunology. 2013

Identification of Enolase as potential allergen from Lake Victoria perch (Lates niloticus) and cod (Gadus morhua). Tomm JM, van Do T, Jende C, Simon JC, Treudler R, von Bergen M, Averbeck M. Journal of Investigational Allergology and Clinical Immunology. 2013

Starvation of Jurkat T cells causes metabolic switch from glycolysis to lipolysis as revealed by comprehensive GC-qMS. Tomm JM, Otto W, Servos U, Bertram B, von Bergen M, Baumann S. Journal of integrated OMICS. 2013

Benzo[a]pyrene affects Jurkat T cells in the activated state via the antioxidant response element dependent Nrf2 pathway leading to decreased IL-2 secretion and redirecting glutamine metabolism. Murugaiyan J, Rockstroh M, Wagner J, Baumann S, Schorsch K, Trump S, Lehmann I, von Bergen M, Tomm JM. Toxicol Appl Pharmacol. 2013 Apr 10.

Requirements and perspectives for integrating metabolomics with other omics data. Baumann S, Kalkhof S, Hackermüller J, Otto W, Tomm JM, Wissenbach DK, Rolle-Kampczyk U, von Bergen M. Current Metabolomics 1 (1), 15 - 27. 2013

MiR-130a, miR-203 and miR-205 jointly repress key oncogenic pathways and are downregulated in prostate carcinoma. Boll K, Reiche K, Kasack K, Mörbt N, Kretzschmar AK, Tomm JM, Verhaegh G, Schalken J, von Bergen M, Horn F, Hackermüller J.Oncogene. 2013.


2012

Evaluation of the tolerability and immunogenicity of ultraviolet C-irradiated autologous platelets in a dog model. Pohler P, Lehmann J, Veneruso V, Tomm JM, von Bergen M, Lambrecht B, Kohn B, Weingart C, Müller TH, Seltsam A. Transfusion. 2012 Mar 8.

A time resolved analysis von nc/ mRNA and protein expresion throughout Th cell activation. von Bergen M, Reiche K, Hösler N, Rockstroh M, Horn F, Hackermüller J, Tomm JM. Immunology 137(S1),364-364. 2012


Occupational IgE-mediated softwood allergy: characterization of the causative allergen. Kespohl S, Kotschy-Lang N, Tomm JM, von Bergen M, Maryska S, Brüning T, Raulf-Heimsoth M. Int Arch Allergy Immunol. 2012


2011

Combined proteomic and metabolomic profiling of serum reveals association of the complement system with obesity and identifies novel markers of body fat mass changes. Oberbach A, Blüher M, Wirth H, Till H, Kovacs P, Kullnick Y, Schlichting N, Tomm JM, Rolle-Kampczyk U, Murugaiyan J, Binder H, Dietrich A, von Bergen M. J Proteome Res. 2011 Oct 7

MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4. Schramedei K, Mörbt N, Pfeifer G, Läuter J, Rosolowski M, Tomm JM, von Bergen M, Horn F, Brocke-Heidrich K. Oncogene. 2011 Jun 30

Cell frationation – an important tool for compartment proteomics. Rockstroh M, Müller SA, Jende C, Kerzhner A, von Bergen M, Tomm JM. Journal of Integrated OMICS. 2011

Chlorinated benzenes cause concomitantly oxidative stress and induction of apoptotic markers in lung epithelial cells (A549) at nonacute toxic concentrations. Mörbt N, Tomm JM, Feltens R, Mögel I, Kalkhof S, Murugesan K, Wirth H, Vogt C, Binder H, Lehmann I, von Bergen M. J Proteome Res. 2011 Feb 4


2007

Multiple domain interactions between VE-cadherin and VE-PTP. Tomm, J.M., Filippowa, K., Vestweber, D., Eur. J. Cell Biol. 86 , 49. 2007


2005

Phytosulphokine gene regulation during maize (Zea mays L.) reproduction. Lorbiecke R, Steffens M, Tomm JM, Scholten S, von Wiegen P, Kranz E, Wienand U, Sauter M. J Exp Bot. 2005 Jul



Neue Software und Techniken

Die neue Software ProteIn Protein INteraction Optimizer - PIPINO

(Kooperation mit Prof. Labudde, Bioinformatics Group Mittweida) ist online

mehr Informationen

                                           

aktuelle Publikationen

2014 (17)

  • Bastida, F., Jehmlich, N., Ondoño, S., von Bergen, M., García, C., Moreno, J.L. (2014):
    Characterization of the microbial community in biological soil crusts dominated by Fulgensia desertorum (Tomin) Poelt and Squamarina cartilaginea (With.) P. James and in the underlying soil
    Soil Biol. Biochem. 76 , 70 - 79
    Volltext (URL)
  • Bozinovski, D., Taubert, M., Kleinsteuber, S., Richnow, H.-H., von Bergen, M., Vogt, C., Seifert, J. (2014):
    Metaproteogenomic analysis of a sulfate-reducing enrichment culture reveals genomic organization of key enzymes in the m-xylene degradation pathway and metabolic activity of proteobacteria
    Syst. Appl. Microbiol. 37 (7), 488 - 501
    Volltext (URL)
  • Franck, U., Weller, A., Röder, S., Herberth, G., Junge, K.M., Kohajda, T., von Bergen, M., Rolle-Kampczyk, U., Diez, U., Borte, M., Lehmann, I. (2014):
    Prenatal VOC exposure and redecoration are related to wheezing in early infancy
    Environ. Int. 73 , 393 - 401
    Volltext (URL)
  • Herberth, G., Bauer, M., Gasch, M., Hinz, D., Röder, S., Olek, S., Kohajda, T., Rolle-Kampczyk, U., von Bergen, M., Sack, U., Borte, M., Lehmann, I. (2014):
    Maternal and cord blood miR-223 expression associates with prenatal tobacco smoke exposure and low regulatory T-cell numbers
    J. Allergy Clin. Immunol. 133 (2), 543 - 550.e4
    Volltext (URL)
  • Imhasly, S., Naegeli, H., Baumann, S., von Bergen, M., Luch, A., Jungnickel, H., Potratz, S., Gerspach, C. (2014):
    Metabolomic biomarkers correlating with hepatic lipidosis in dairy cows
    BMC Vet. Res. 10 , art. 122
    Volltext (PDF)
  • Jungandreas, A., Schellenberger Costa, B., Jakob, T., von Bergen, M., Baumann, S., Wilhelm, C. (2014):
    The acclimation of Phaeodactylum tricornutum to blue and red light does not influence the photosynthetic light reaction but strongly disturbs the carbon allocation pattern
    PLOS One 9 (8), e99727
    Volltext (PDF)
  • Junge, K.M., Hörnig, F., Herberth, G., Röder, S., Kohajda, T., Rolle-Kampczyk, U., von Bergen, M., Borte, M., Simon, J.-C., Heroux, D., Denburg, J.A., Lehmann, I. (2014):
    The LINA cohort: cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy
    Clin. Immunol. 152 (1-2), 68 - 76
    Volltext (URL)
  • Jungnickel, H., Luch, A., Potratz, S., von Bergen, M., Baumann, S., Tarnow, P. (2014):
    Identification of lipidomic biomarkers for coexposure to subtoxic doses of benzo[a]pyrene and cadmium: the toxicological cascade biomarker approach
    Environ. Sci. Technol. 48 (17), 10423 - 10431
    Volltext (URL)
  • Kalkhof, S., Förster, Y., Schmidt, J., Schulz, M.C., Baumann, S., Weißflog, A., Gao, W., Hempel, U., Eckelt, U., Rammelt, S., von Bergen, M. (2014):
    Proteomics and metabolomics for in situ monitoring of wound healing
    Biomed Res. Int. 2014 , art. 934848
    Volltext (PDF)
  • Kleindienst, S., Herbst, F.-A., Stagars, M., von Netzer, F., von Bergen, M., Seifert, J., Peplies, J., Amann, R., Musat, F., Lueders, T., Knittel, K. (2014):
    Diverse sulfate-reducing bacteria of the Desulfosarcina/Desulfococcus clade are the key alkane degraders at marine seeps
    ISME J. 8 , 2029 - 2044
    Volltext (URL)
  • Marozava, S., Röling, W.F.M., Seifert, J., Küffner, R., von Bergen, M., Meckenstock, R.U. (2014):
    Physiology of Geobacter metallireducens under excess and limitation of electron donors. Part I. Batch cultivation with excess of carbon sources
    Syst. Appl. Microbiol. 37 (4), 277 - 286
    Volltext (PDF)
  • Marozava, S., Röling, W.F.M., Seifert, J., Küffner, R., von Bergen, M., Meckenstock, R.U. (2014):
    Physiology of Geobacter metallireducens under excess and limitation of electron donors. Part II. Mimicking environmental conditions during cultivation in retentostats
    Syst. Appl. Microbiol. 37 (4), 287 - 295
    Volltext (PDF)
  • Mussotter, F., Haase, A., Tomm, J.M., El Ali, Z., Kerdine-Römer, S., Pallardy, M., von Bergen, M., Luch, A. (2014):
    A proteomics approach to elucidate the role of Nrf2 in primary bone-marrow-derived dendritic cells of mice upon activation by contact allergens
    Toxicol. Lett. 229 (Suppl.), S203
    Volltext (URL)
  • Rösch, C., Kohajda, T., Röder, S., von Bergen, M., Schlink, U. (2014):
    Relationship between sources and patterns of VOCs in indoor air
    Atmos. Pollut. Res. 5 (1), 129 - 137
    Volltext (URL)
  • Schiffmann, C., Hansen, R., Baumann, S., Kublik, A., Nielsen, P.H., Adrian, L., von Bergen, M., Jehmlich, N., Seifert, J. (2014):
    Comparison of targeted peptide quantification assays for reductive dehalogenases by selective reaction monitoring (SRM) and precursor reaction monitoring (PRM)
    Anal. Bioanal. Chem. 406 (1), 283 - 291
    Volltext (URL)
  • Schiffmann, C.L., Jehmlich, N., Otto, W., Hansen, R., Nielsen, P.H., Adrian, L., Seifert, J., von Bergen-Tomm, M. (2014):
    Proteome profile and proteogenomics of the organohalide-respiring bacterium Dehalococcoides mccartyi strain CBDB1 grown on hexachlorobenzene as electron acceptor
    J. Proteomics 98 , 59 - 64
    Volltext (URL)
  • Uhlmann, K., Gibb, S., Kalkhof, S., Arroyo-Abad, U., Schulz, C., Hoffmann, B., Stubbins, F., Carpenter, S., Beer, M., von Bergen, M., Feltens, R. (2014):
    Species determination of Culicoides biting midges via peptide profiling using matrix-assisted laser desorption ionization mass spectrometry
    Parasites Vectors 7 , 392
    Volltext (PDF)

2013 (27)

  • Blumert, C., Kalkhof, S., Brocke-Heidrich, K., Kohajda, T., von Bergen, M., Horn, F. (2013):
    Analysis of the STAT3 interactome using in-situ biotinylation and SILAC
    J. Proteomics 94 , 370 - 386
    Volltext (URL)
  • Bodelier, P.L.E., Meima-Franke, M., Hordijk, C.A., Steenbergh, A.K., Hefting, M.E., Bodrossy, L., von Bergen, M., Seifert, J. (2013):
    Microbial minorities modulate methane consumption through niche partitioning
    ISME J. 7 , 2214 - 2228
    Volltext (URL)
  • Boll, K., Reiche, K., Kasack, K., Mörbt, N., Kretzschmar, A.K., Tomm, J.M., Verhaegh, G., Schalken, J., von Bergen, M., Horn, F., Hackermüller, J. (2013):
    MiR-130a, miR-203 and miR-205 jointly repress key oncogenic pathways and are downregulated in prostate carcinoma
    Oncogene 32 , 277 - 285
    Volltext (URL)
  • Eberlein, C., Estelmann, S., Seifert, J., von Bergen, M., Müller, M., Meckenstock, R.U., Boll, M. (2013):
    Identification and characterization of 2-naphthoyl-coenzyme A reductase, the prototype of a novel class of dearomatizing reductases
    Mol. Microbiol. 88 (5), 1032 - 1039
    Volltext (URL)
  • Ferrer, M., Ruiz, A., Lanza, F., Haange, S.-B., Oberbach, A., Till, H., Bargiela, R., Campoy, C., Segura, M.T., Richter, M., von Bergen, M., Seifert, J., Suarez, A. (2013):
    Microbiota from the distal guts of lean and obese adolescents exhibit partial functional redundancy besides clear differences in community structure
    Environ. Microbiol. 15 (1), 211 - 226
    Volltext (URL)
  • Guazzaroni, M.-E., Herbst, F.-A., Lores, I., Tamames, J., Peláez, A.I., López-Cortés, N., Alcaide, M., del Pozo, M.V., Vieites, J.M., von Bergen, M., Gallego, J.L.R., Bargiela, R., López-López, A., Pieper, D.H., Rosselló-Móra, R., Sánchez, J., Seifert, J., Ferrer, M. (2013):
    Metaproteogenomic insights beyond bacterial response to naphthalene exposure and bio-stimulation
    ISME J. 7 , 122 - 136
    Volltext (URL)
  • Herberth, G., Bauer, M., Gasch, M., Hinz, D., Röder, S., Olek, S., Kohajda, T., Rolle-Kampczyk, U., von Bergen-Tomm, M., Sack, U., Borte, M., Lehmann, I. (2013):
    Maternal and cord blood miR-223 expression associates with prenatal tobacco smoke exposure and with low Treg numbers
    Allergy 68 (Suppl. 97), 628 - 628
    Volltext (URL)
  • Herbst, F.-A., Bahr, A., Duarte, M., Pieper, D.H., Richnow, H.-H., von Bergen, M., Seifert, J., Bombach, P. (2013):
    Elucidation of in situ polycyclic aromatic hydrocarbon degradation by functional metaproteomics (protein-SIP)
    Proteomics 13 (18-19), 2910 - 2920
    Volltext (URL)
  • Herbst, F.-A., Taubert, M., Jehmlich, N., Behr, T., Schmidt, F., von Bergen, M., Seifert, J. (2013):
    Sulfur-34S stable isotope labeling of amino acids for quantification (SULAQ34) of proteomic changes in Pseudomonas fluorescens during naphthalene degradation
    Mol. Cell. Proteomics 12 (8), 2060 - 2069
    Volltext (URL)
  • Jahn, M., Seifert, J., von Bergen, M., Schmid, A., Bühler, B., Müller, S. (2013):
    Subpopulation-proteomics in prokaryotic populations
    Curr. Opin. Biotechnol. 24 (1), 79 - 87
    Volltext (URL)
  • Jechalke, S., Franchini, A., Bastida, F., Bombach, P., Rosell, M., Seifert, J., von Bergen, M., Vogt, C., Richnow, H.H. (2013):
    Analysis of structure, function, and activity of a benzene-degrading microbial community
    FEMS Microbiol.Ecol. 85 (1), 14 - 26
    Volltext (URL)
  • Kliemt, S., Lange, C., Otto, W., Hintze, V., Möller, S., von Bergen, M., Hempel, U., Kalkhof, S. (2013):
    Sulfated hyaluronan containing collagen matrices enhance cell-matrix-interaction, endocytosis, and osteogenic differentiation of human mesenchymal stromal cells
    J. Proteome Res. 12 (1), 378 - 389
    Volltext (URL)
  • Kung, J.W., Seifert, J., von Bergen, M., Boll, M. (2013):
    Cyclohexanecarboxyl-coenzyme A (CoA) and cyclohex-1-ene-1-carboxyl-CoA dehydrogenases, two enzymes involved in the fermentation of benzoate and crotonate in Syntrophus aciditrophicus
    J. Bacteriol. 195 (14), 3193 - 3200
    Volltext (URL)
  • Leibeling, S., Maeß, M.B., Centler, F., Kleinsteuber, S., von Bergen, M., Thullner, M., Harms, H., Müller, R.H. (2013):
    Posttranslational oxidative modification of (R)-2-(2,4-dichlorophenoxy)propionate/α-ketoglutarate-dependent dioxygenases (RdpA) leads to improved degradation of 2,4-dichlorophenoxyacetate (2,4-D)
    Eng. Life Sci. 13 (3), 278 - 291
    Volltext (URL)
  • Markle, J.G.M., Frank, D.N., Mortin-Toth, S., Robertson, C.E., Feazel, L.M. , Rolle-Kampczyk, U., von Bergen, M., McCoy, C.D., Macpherson, A.J., Danska, J.S. (2013):
    Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
    Science 339 (6123 ), 1084 - 1088
    Volltext (URL)
  • Müller, S.A., Findeiß, S., Pernitzsch, S.R., Wissenbach, D.K., Stadler, P.F., Hofacker, I.L., von Bergen, M., Kalkhof, S. (2013):
    Identification of new protein coding sequences and signal peptidase cleavage sites of Helicobacter pylori strain 26695 by proteogenomics
    J. Proteomics 86 , 27 - 42
    Volltext (URL)
  • Murugaiyan, J., Rockstroh, M., Wagner, J., Baumann, S., Schorsch, K., Trump, S., Lehmann, I., von Bergen, M., Tomm, J.M. (2013):
    Benzo[a]pyrene affects Jurkat T cells in the activated state via the antioxidant response element dependent Nrf2 pathway leading to decreased IL-2 secretion and redirecting glutamine metabolism
    Toxicol. Appl. Pharmacol. 269 (3), 307 - 316
    Volltext (URL)
  • Murugaiyan, J., Weise, C., von Bergen, M., Roesler, U. (2013):
    Two-dimensional proteome reference map of Prototheca zopfii revealed reduced metabolism and enhanced signal transduction as adaptation to an infectious life style
    Proteomics 13 (17), 2664 - 2669
    Volltext (URL)
  • Murugesan, K., Baumann, S., Wissenbach, D.K., Kliemt, S., Kalkhof, S., Otto, W., Mögel, I., Kohajda, T., von Bergen, M., Tomm, J.M. (2013):
    Subtoxic and toxic concentrations of benzene and toluene induce Nrf-2 mediated anti-oxidative stress response and affect the central carbon metabolism in lung epithelial cells A549
    Proteomics 13 (21), 3211 - 3221
    Volltext (URL)
  • Pérez-Cobas, A.E., Gosalbes, M.J., Friedrichs, A., Knecht, H., Artacho, A., Eismann, K., Otto, W., Rojo, D., Bargiela, R., von Bergen, M., Neulinger, S.C., Däumer, C., Heinsen, F.A., Latorre, A., Barbas, C., Seifert, J., Martins dos Santos, V., Ott, S.J., Ferrer, M., Moya, A. (2013):
    Gut microbiota disturbance during antibiotic therapy: a multi-omic approach
    Gut 62 , 1591 - 1601
    Volltext (PDF)
  • Seifert, J., Herbst, F.-A., Nielsen, P.H., Planes, F.J., Ferrer, M., von Bergen, M. (2013):
    Bioinformatic progress and applications in metaproteogenomics for bridging the gap between genomic sequences and metabolic functions in microbial communities
    Proteomics 13 (18-19), 2786 - 2804
    Volltext (URL)
  • Siegert, M., Taubert, M., Seifert, J., von Bergen-Tomm, M., Basen, M., Bastida, F., Gehre, M., Richnow, H.-H., Krüger, M. (2013):
    The nitrogen cycle in anaerobic methanotrophic mats of the Black Sea is linked to sulfate reduction and biomass decomposition
    FEMS Microbiol.Ecol. 86 (2), 231 - 245
    Volltext (URL)
  • Taubert, M., von Bergen-Tomm, M., Seifert, J. (2013):
    Limitations in detection of 15N incorporation by mass spectrometry in protein-based stable isotope probing (protein-SIP)
    Anal. Bioanal. Chem. 405 (12), 3989 - 3996
    Volltext (URL)
  • Tomm, J.M., Krause, C., Simon, J.C., Treudler, R., von Bergen, M., Averbeck, M. (2013):
    Pyruvate kinase and phosphopyruvate hydratase as novel IgE reactive proteins in prawn
    J. Invest. Allergol. Clin. Immunol. 23 (6), 443 - 445
    Volltext (PDF)
  • Tomm, J.M., van Do, T., Jende, C., Simon, J.C., Treudler, R., von Bergen, M., Averbeck, M. (2013):
    Identification of new potential allergens from Nile perch (Lates niloticus) and Cod (Gadus morhua)
    J. Invest. Allergol. Clin. Immunol. 23 (3), 159 - 167
  • von Bergen, M., Jehmlich, N., Taubert, M., Vogt, C., Bastida, F., Herbst, F.-A., Schmidt, F., Richnow, H.-H., Seifert, J. (2013):
    Insights from quantitative metaproteomics and protein-stable isotope probing into microbial ecology
    ISME J. 7 (10), 1877 - 1885
    Volltext (URL)
  • Weisse, K., Winkler, S., Hirche, F., Herberth, G., Hinz, D., Bauer, M., Röder, S., Rolle-Kampczyk, U., von Bergen, M., Olek, S., Richter, T., Diez, U., Borte, M., Stangl, G.I., Lehmann, I. (2013):
    Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study
    Allergy 68 (2), 220 - 228
    Volltext (URL)

2012 (25)

  • Baumgarten, T., Sperling, S., Seifert, J., von Bergen, M., Steiniger, F., Wick, L.Y., Heipieper, H.J. (2012):
    Membrane vesicle formation as multiple stress response mechanism enhances cell surface hydrophobicity and biofilm formation of Pseudomonas putida DOT-T1E
    Appl. Environ. Microb. 78 (17), 6217 - 6224
    Volltext (URL)
  • Bönisch, U., Böhme, A., Kohajda, T., Mögel, I., Schütze, N., von Bergen, M., Simon, J.C., Lehmann, I., Polte, T. (2012):
    Volatile organic compounds enhance allergic airway inflammation in an experimental mouse model
    PLoS One 7 (7), e39817
    Volltext (URL)
  • Bozinovski, D., Herrmann, S., Richnow, H.-H., von Bergen, M., Seifert, J., Vogt, C. (2012):
    Functional analysis of an anaerobic m-xylene-degrading enrichment culture using protein-based stable isotope probing
    FEMS Microbiol.Ecol. 81 (1), 134 - 144
    Volltext (URL)
  • Goettsch, C., Kliemt, S., Sinningen, K., von Bergen, M., Hofbauer, L.C., Kalkhof, S. (2012):
    Quantitative proteomics reveals novel functions of osteoclast-associated receptor in STAT signaling and cell adhesion in human endothelial cells
    J. Mol. Cell. Cardiol. 53 (6), 829 - 837
    Volltext (URL)
  • Gündel, U., Kalkhof, S., Zitzkat, D.P., von Bergen, M., Altenburger, R., Küster, E. (2012):
    Concentration-response concept in ecotoxicoproteomics: effects of different phenanthrene concentrations to the zebrafish (Danio rerio) embryo proteome
    Ecotox. Environ. Safe. 76 (1), 11 - 22
    Volltext (URL)
  • Haange, S.-B., Oberbach, A., Schlichting, N., Hugenholtz, F., Smidt, H., von Bergen, M., Till, H., Seifert, J. (2012):
    Metaproteome analysis and molecular genetics of rat intestinal microbiota reveals section and localisation resolved species distribution and enzymatic functionalities
    J. Proteome Res. 11 (11), 5406 - 5417
    Volltext (URL)
  • Haas, S., Jahnke, H.-G., Moerbt, N., von Bergen, M., Aharinejad, S., Andrukhova, O., Robitzki, A.A. (2012):
    DIGE proteome analysis reveals suitability of ischemic cardiac in vitro model for studying cellular response to acute ischemia and regeneration
    PLoS One 7 (2), e31669
    Volltext (URL)
  • Hörnig, F., Weisse, K., Röder, S., Kohajda, T., von Bergen-Tomm, M., Borte, M., Diez, U., Simon, J., Denburg, J., Lehmann, I. (2012):
    Infantile eosinophil/basophil progenitors are more sensitive to indoor chemical exposures compared to their mothers
    Allergy 67 (Suppl. 96), 574 - 574
    Volltext (URL)
  • Jehmlich, N., Kopinke, F.-D., Lenhard, S., Vogt, C., Herbst, F.-A., Seifert, J., Lissner, U., Völker, U., Schmidt, F., von Bergen, M. (2012):
    Sulfur-36S stable isotope labeling of amino acids for quantification (SULAQ)
    Proteomics 12 (1), 37 - 42
    Volltext (URL)
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    Volltext (URL)
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    J. Bacteriol. 194 (16), 4169 - 4177
    Volltext (URL)
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    Volltext (URL)
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    Volltext (URL)
  • Oberbach, A., von Bergen, M., Blueher, S., Lehmann, S., Till, H. (2012):
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    Volltext (URL)
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    Volltext (URL)
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    Volltext (URL)
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    Volltext (URL)
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    Volltext (URL)
  • Seifert, J., Taubert, M., Jehmlich, N., Schmidt, F., Völker, U., Vogt, C., Richnow, H.H., von Bergen, M. (2012):
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    Volltext (URL)
  • Taubert, M., Vogt, C., Wubet, T., Kleinsteuber, S., Tarkka, M.T., Harms, H., Buscot, F., Richnow, H.-H., von Bergen, M., Seifert, J. (2012):
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    ISME J. 6 (12), 2291 - 2301
    Volltext (URL)
  • von Bergen, M., Reiche, K., Hösler, N., Rockstroh, M., Horn, F., Hackermüller, J., Tomm, J. (2012):
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    Volltext (URL)
  • Weisse, K., Lehmann, I., Heroux, D., Kohajda, T., Herberth, G., Röder, S., von Bergen, M., Borte, M., Denburg, J. (2012):
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    Clin. Exp. Allergy 42 (9), 1337 - 1346
    Volltext (URL)
  • Weisse, K., Winkler, S., Stangl, G.I., Hirche, F., Herberth, G., Hinz, D., Bauer, M., Röder, S., Rolle-Kampczyk, U., von Bergen-Tomm, M., Olek, S., Sack, U., Borte, M., Richter, T., Lehmann, I. (2012):
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    J. Reprod. Immunol. 94 (1), 53 - 54
    Volltext (URL)
  • Wirth, H., von Bergen, M., Binder, H. (2012):
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    Volltext (PDF)
  • Wirth, H., von Bergen, M., Murugaiyan, J., Roesler, U., Stokowy, T., Binder, H. (2012):
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    J. Microbiol. Methods 88 (1), 83 - 89
    Volltext (URL)