Short abstract: Conservative estimates suggest that between 92-220 million people world-wide are chronically exposed to the environmental toxicant arsenic in drinking water. This is a global public health concern because arsenic is a proven human carcinogen, and causes a myriad of other adverse health effects. The essential trace element selenium, has been proposed as a therapeutic to prevent and treat arenic-induced disease. In laboratory animals, arsenic and selenium, can undergo mutual detoxification through the formation of the seleno-bis(S-glutathionyl) arsinium ion [(GS)₂AsSe]⁻, which undergoes biliary and fecal elimination. Despite the current use of selenium in supplementation of humans in arsenic-endemic regions, until recently the influence of selenium on human arsenic hepatobiliary transport had not been thoroughly studied. Work from the Leslie lab, using a combination of sandwich cultured primary human hepatocytes, HepaRG cells (a surrogate for primary human hepatocytes), and plasma membrane enriched vesicles, has shown that the human ATP-binding cassette (ABC) transporters multidrug resistance protein 2 (MRP2/ABCC2) and multidrug resistance protein 4 (MRP4/ABCC4) are important for the selenium dependent and independent hepatobiliary transport of arsenic. The form of selenium appears critical for its influence on arsenic export by MRP2 and MRP4. Recent progress in the understanding of how selenium influences arsenic hepatobiliary transport, with a focus on MRP2 and MRP4, will be presented.

Short CV: Dr. Elaine M. Leslie received her BSc in Toxicology from the University of Guelph, Guelph, Canada and her PhD in Pharmacology and Toxicology from Queen’s University, Kingston, Canada.Dr. Leslie completed postdoctoral training at the National Institutes of Environmental Health Sciences, Research Triangle Park, North Carolina, USA and at the University of North Carolina, Chapel Hill, North Carolina, USA. Dr. Leslie is currently a Professor in the Departments of Physiology and Laboratory Medicine and Pathology and a member of the Membrane Protein Disease Research Group at the University of Alberta, Edmonton. Dr. Leslie’s research has most recently been funded by grants from the Canadian Institutes of Health Research and the Natural Sciences and Engineering Research Council. Dr. Leslie has served as a reviewer or scientific officer on the Pharmacology and Toxicology Panel at CIHR since 2019 and is Chair-Elect for the Division of Toxicology within the American Society of Pharmacology and Experimental Therapeutics (ASPET). Dr. Leslie has a long-standing interest in the involvement of transporter proteins and conjugating enzymes in detoxification. The Leslie laboratory has made significant contributions to understanding how ATP-binding cassette (ABC) transporter proteins are involved in protecting tissues from xenobiotic induced injury. The major focus of Dr. Leslie’s research is the biotransformation and transport of the environmental human carcinogen arsenic.

Host: Dr. Till Luckenbach / Department Ecotoxicology

At the HIGRADE Conference, doctoral researchers in their final year present their work and there are many possibilities for scientific exchange and networking. All UFZ colleagues and our cooperation partners are invited to join the event!

www.higrade.de/conference

Wie kann Resilienz in eine integrierte und nachhaltige Entwicklung von Städten und Quartieren eingebunden werden?

Die Leipziger Nacht der Ausbildung richtet sich an alle Schülerinnen iund Schüler ab Klassenstufe 7 aller Schularten sowie explizit an Eltern/Familienangehörige.
Eine vorherige Platzbuchung ist erforderlich. Das Buchungsportal der Stadt Leipzig öffnet voraussichtlich Anfang Mai 2024.

Die Konferenz zielt darauf ab, Rewilding als Naturschutzansatz bekannt zu machen und seine Möglichkeiten und Grenzen zu diskutieren. Dazu werden einerseits Vertreter*innen der Global Rewilding Alliance, von Rewilding Europe und auch dem deutschen Rewilding-Modellgebiet „Oder-Delta“ aus der Rewilding-Praxis berichten. Andererseits gibt es Raum sich in vertiefenden Workshops zu vernetzten und sich zur praktischen Umsetzung von Rewilding in Deutschland auszutauschen.

Sie finden alle Informationen zur Rewilding Konferenz 2024 auf unserer Konferenz-Homepage.

Our conference, themed "Geosciences Without Borders" invites geoscientists from Europe and worldwide to convene for a dynamic exchange of knowledge.

2024, the vibrant city of Dresden plays host to GeoSaxonia, embracing its historical significance and cutting-edge research landscape. Organized in partnership with the Technical University of Dresden and Senckenberg, and bolstered by the collective expertise of TU Bergakademie Freiberg and Charles University in Prague, GeoSaxonia 2024 promises to be a convergence of ideas and innovation.

The event features insightful plenary and keynote lectures, a comprehensive poster and industry exhibition, extensive field trips and thought-provoking discussions, aiming to foster cross-border collaborations and inspire new projects and a lively exchange.